Trial reportHuman brain mapping2016
Oxytocin enhances cognitive control of food craving in women.
Trial report in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- A comprehensive analysis of oxytocin: a potential brain-based treatment to regulate obesity.Frontiers in endocrinology · 2025Pooled it
- Cognitive reappraisal of food craving and emotions: a coordinate-based meta-analysis of fMRI studies.Social cognitive and affective neuroscience · 2024Pooled it
- Neural Correlates of Anti-appetite Medications: An fMRI Meta-analysis.Current neuropharmacology · 2021Pooled it
- Cross-sectional and longitudinal neural predictors of physical activity and sedentary behaviour from a 6-month randomized controlled trial.Scientific reports · 2024Trial
- Oxytocin, cortisol, and cognitive control during acute and naturalistic stress.Stress (Amsterdam, Netherlands) · 2021Trial
- Oxytocin enhances the pain-relieving effects of social support in romantic couples.Human brain mapping · 2019Trial
- Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Social bonds and health: exploring the impact of social relations on oxytocin and brain-gut communication in shaping obesity.Gut microbes · 2025Article
- The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease.Endocrine reviews · 2025Review
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Neuroimaging and neuroendocrine insights into food cravings and appetite interventions in obesity.Psychoradiology · 2023Review
- Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction.International journal of molecular sciences · 2022Review
- Altered functional hubs and connectivity in type 2 diabetes mellitus with and without mild cognitive impairment.Frontiers in neurology · 2022Article
- Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms.International journal of molecular sciences · 2021Review
- The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans.International journal of molecular sciences · 2021Review
- Oxytocin as an Anti-obesity Treatment.Frontiers in neuroscience · 2021Review
- Sex Differences and Estrous Influences on Oxytocin Control of Food Intake.Neuroscience · 2020Article
- Metabolic Effects of Oxytocin.Endocrine reviews · 2020Review
- The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis.Journal of neuroendocrinology · 2020Review
- Role of oxytocin in the control of stress and food intake.Journal of neuroendocrinology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In developed countries, obesity has become an epidemic resulting in enormous health care costs for society and serious medical complications for individuals. The homeostatic regulation of food intake is critically dependent on top-down control of reward-driven food craving. There is accumulating evidence from animal studies that the neuropeptide oxytocin (OXT) is involved in regulating hunger states and eating behavior, but whether OXT also contributes to cognitive control of food craving in humans is still unclear. We conducted a counter-balanced, double-blind, within-subject, pharmacological magnetic resonance imaging experiment involving 31 healthy women who received 24 IU of intranasal OXT or placebo and were scanned twice while they were exposed to pictures of palatable food. The participants were instructed either to imagine the immediate consumption or to cognitively control the urge to eat the food. Our results show a trend that OXT specifically reduced food craving in the cognitive control condition. On the neural level, these findings were paralleled by an increase of activity in the middle and superior frontal gyrus, precuneus, and cingulate cortex under OXT. Interestingly, the behavioral OXT effect correlated with the OXT-induced changes in the prefrontal cortex and precuneus. Collectively, the present study provides first evidence that OXT plays a key role in the cognitive regulation of food craving in women by strengthening activity in a broad neurocircuitry implicated in top-down control and self-referential processing. Hum Brain Mapp 37:4276-4285, 2016. © 2016 Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.