Evidence map›Paper›PMID 27381249›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2016

The allergic march comprises the coexistence of related patterns of allergic disease not just the progressive development of one disease.

Emma Goksör, Petra Loid, Bernt Alm, Nils Åberg, Göran Wennergren

Abstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. Acquisition, remission, and persistence of eczema, asthma, and rhinitis in children.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018
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  16. Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy: A birth cohort study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emma GoksörDepartment of Paediatrics, University of Gothenburg, Queen Silvia Children's Hospital, Gothenburg, Sweden.
Petra LoidDepartment of Paediatrics, University of Gothenburg, Queen Silvia Children's Hospital, Gothenburg, Sweden.
Bernt AlmDepartment of Paediatrics, University of Gothenburg, Queen Silvia Children's Hospital, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-3557-2995
Nils ÅbergDepartment of Paediatrics, University of Gothenburg, Queen Silvia Children's Hospital, Gothenburg, Sweden.
Göran WennergrenDepartment of Paediatrics, University of Gothenburg, Queen Silvia Children's Hospital, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study explored the development and comorbidity of allergic diseases by analysing the relationship between allergic manifestations in infancy and at the age of 8.

methodsWe included 5654 children born in Sweden in 2003 in a longitudinal study. Parents answered postal questionnaires when the children were six months and one, four-and-a-half and eight years of age.

resultsThe response rate at eight years was 4051 (71.6%), and we analysed 3382 children with complete data. The number of manifestations in infancy increased the risk of allergic disease at eight years of age: 72% of children with one early manifestation were symptom free at 8, compared to 45% with two or more manifestations. Similar manifestations occurred in infancy and at the age of 8, for example recurrent wheeze increased the risk of doctor-diagnosed asthma by an adjusted odds ratio of 6.5. Eczema and food allergy independently increased the risk of all four allergic manifestations at eight years.

conclusionAllergic disease at the age of 8 was related to the number of allergic manifestations in infancy. Manifestations were similar at both ages, suggesting an allergic march with the coexistence of disease patterns rather than the progressive development of one disease.

Indexed as

Age FactorsAnimalsAsthmaCatsChildChild, PreschoolComorbidityDogsEczemaFemaleHumansHypersensitivityInfantLongitudinal StudiesMalePrevalenceAllergic marchAllergic rhinitisAsthmaEczemaFood allergy

Identifiers

PMID27381249
PMCPMC5129460

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.