ArticleNature reviews. Molecular cell biology2016
Applying CRISPR-Cas9 tools to identify and characterize transcriptional enhancers.
Article in Nature reviews. Molecular cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Enhancer-based gene therapy: a new path for precision medicine.Hereditas · 2026Review
- Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4.Molecular cell · 2024Article
- An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression.Journal of translational medicine · 2024Article
- A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells.Lipids in health and disease · 2024Article
- 3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages.Nature structural & molecular biology · 2024Article
- Review
- Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression.bioRxiv : the preprint server for biology · 2023Article
- Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens.Nature communications · 2023Article
- Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.PLoS genetics · 2023Article
- Elucidating the importance and regulation of key enhancers for human MEIS1 expression.Leukemia · 2022Article
- Enhancer redundancy in development and disease.Nature reviews. Genetics · 2021Review
- SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression.Nature communications · 2021Article
- Cis-Regulatory Control of Mammalian Sex Determination.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2021Review
- A Mutation in theG3 (Bethesda, Md.) · 2020Article
- Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems.Nucleic acids research · 2020Article
- Determinants of enhancer and promoter activities of regulatory elements.Nature reviews. Genetics · 2020Review
- Perspectives of CRISPR/Cas-mediatedHorticulture research · 2020Review
- Identification of DHODH as a therapeutic target in small cell lung cancer.Science translational medicine · 2019Article
- Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells.Scientific reports · 2019Article
- Single-Cell Multi-omics: An Engine for New Quantitative Models of Gene Regulation.Trends in genetics : TIG · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of the CRISPR-Cas9 system triggered a revolution in the field of genome engineering. Initially, the use of this system was focused on the study of protein-coding genes but, recently, a number of CRISPR-Cas9-based tools have been developed to study non-coding transcriptional regulatory elements. These technological advances offer unprecedented opportunities for elucidating the functions of enhancers in their endogenous context. Here, we discuss the application, current limitations and future development of CRISPR-Cas9 systems to identify and characterize enhancer elements in a high-throughput manner.
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