ArticleDevelopment (Cambridge, England)2016
Retinal determination genes coordinate neuroepithelial specification and neurogenesis modes in the Drosophila optic lobe.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Review
- Gene regulatory networks during the development of the Drosophila visual system.Current topics in developmental biology · 2020Review
- Article
- Novel Strategies for the Generation of Neuronal Diversity: Lessons From the Fly Visual System.Frontiers in molecular neuroscience · 2019Review
- The RNA Helicase BELLE Is Involved in Circadian Rhythmicity and in Transposons Regulation inFrontiers in physiology · 2019Article
- The Organization of the Second Optic Chiasm of theFrontiers in neural circuits · 2019Article
- The transcription factor SoxD controls neuronal guidance in the Drosophila visual system.Scientific reports · 2018Article
- Temporal and spatial order of photoreceptor and glia projections into optic lobe in Drosophila.Scientific reports · 2018Article
- Spatio-temporal relays control layer identity of direction-selective neuron subtypes in Drosophila.Nature communications · 2018Article
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2 authors.
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Abstract
Differences in neuroepithelial patterning and neurogenesis modes contribute to area-specific diversifications of neural circuits. In the Drosophila visual system, two neuroepithelia, the outer (OPC) and inner (IPC) proliferation centers, generate neuron subtypes for four ganglia in several ways. Whereas neuroepithelial cells in the medial OPC directly convert into neuroblasts, in an IPC subdomain they generate migratory progenitors by epithelial-mesenchymal transition that mature into neuroblasts in a second proliferative zone. The molecular mechanisms that regulate the identity of these neuroepithelia, including their neurogenesis modes, remain poorly understood. Analysis of Polycomblike revealed that loss of Polycomb group-mediated repression of the Hox gene Abdominal-B (Abd-B) caused the transformation of OPC to IPC neuroepithelial identity. This suggests that the neuroepithelial default state is IPC-like, whereas OPC identity is derived. Ectopic Abd-B blocks expression of the highly conserved retinal determination gene network members Eyes absent (Eya), Sine oculis (So) and Homothorax (Hth). These factors are essential for OPC specification and neurogenesis control. Finally, eya and so are also sufficient to confer OPC-like identity, and, in parallel with hth, the OPC-specific neurogenesis mode on the IPC.
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