Evidence map›Paper›PMID 27381224›Full record

ReviewDevelopment (Cambridge, England)2016

Generation of intestinal surface: an absorbing tale.

Katherine D Walton, Andrew M Freddo, Sha Wang, Deborah L Gumucio

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 143 citations in OpenAlex.

  1. Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026
    Review
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  15. The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025
    Review
  16. Article
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  18. Safety and immunomodulatory efficacy of heat-killedFrontiers in veterinary science · 2025
    Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Katherine D WaltonCell and Developmental Biology Department, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Andrew M FreddoCell and Developmental Biology Department, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Sha WangCell and Developmental Biology Department, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Deborah L GumucioCell and Developmental Biology Department, University of Michigan Medical School, Ann Arbor, MI 48109, USA dgumucio@med.umich.edu.ORCID 0000-0001-8883-383X
University of Michigan · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
Morphogenesis of the fetal intestinal epitheliumR01DK089933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUMUCIO, DEBORAH L. · 2011 to 2019
$3.6M
A novel Ezrin-dependent cell division drives villus formationF30DK100125 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FREDDO, ANDREW MICHAEL · 2013 to 2017
$103k
NIDDK NIH HHS F30 DK100125NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK089933NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

The vertebrate small intestine requires an enormous surface area to effectively absorb nutrients from food. Morphological adaptations required to establish this extensive surface include generation of an extremely long tube and convolution of the absorptive surface of the tube into villi and microvilli. In this Review, we discuss recent findings regarding the morphogenetic and molecular processes required for intestinal tube elongation and surface convolution, examine shared and unique aspects of these processes in different species, relate these processes to known human maladies that compromise absorptive function and highlight important questions for future research.

Indexed as

Intestinal AbsorptionAnimalsHumansIntestinesMicrovilliModels, BiologicalMorphogenesisSignal TransductionAbsorptive surfaceIntestinal lengtheningMesenchymal clustersMicrovillus inclusion diseaseShort bowel syndromeVillus morphogenesis

Identifiers

PMID27381224
PMCPMC4958325
OpenAlexW2463442273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.