ArticleEuropean radiology2017
CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkin's and aggressive non-hodgkin's lymphomas.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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40 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Current status and quality of radiomics studies in lymphoma: a systematic review.European radiology · 2020Pooled it
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- Predicting chemotherapy response in pediatric lymphoma using pre-treatment contrast-enhanced CT radiomics: A hypothesis-generating study.Abdominal radiology (New York) · 2026Article
- Predicting overall survival after initial chemotherapy for diffuse large B-cell lymphoma using CT nomogram analysis.BMC medical imaging · 2026Article
- Non-Hodgkin's lymphoma classification using 3D radiomics machine learning models for precision imaging in oncology.BMC medical imaging · 2025Article
- Prediction of the prognosis of liver iron burden within two years after hematopoietic stem cell transplantation based on multimodal MRI-based radiomics model.Frontiers in medicine · 2025Article
- Development and validation of CT‑based radiomics model of PET-negative residual CT masses: a potential biomarker for predicting relapse‑free survival in non-Hodgkin lymphoma patients showing complete metabolic response.Abdominal radiology (New York) · 2024Article
- Pretreatment CT Texture Parameters as Predictive Biomarkers of Progression-Free Survival in Follicular Lymphoma Treated with Immunochemotherapy and Rituximab Maintenance.Diagnostics (Basel, Switzerland) · 2023Article
- BaselineDiagnostics (Basel, Switzerland) · 2023Article
- α- and β-Genotyping of Thalassemia Patients Based on a Multimodal Liver MRI Radiomics Model: A Preliminary Study in Two Centers.Diagnostics (Basel, Switzerland) · 2023Article
- CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations.Scientific reports · 2022Article
- Metastatic melanoma treated by immunotherapy: discovering prognostic markers from radiomics analysis of pretreatment CT with feature selection and classification.International journal of computer assisted radiology and surgery · 2022Article
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- Radiomics analysis for differentiating of cervical lymphadenopathy between cancer of unknown primary and malignant lymphoma on unenhanced computed tomography.Nagoya journal of medical science · 2022Article
- Deep Neural Networks and Machine Learning Radiomics Modelling for Prediction of Relapse in Mantle Cell Lymphoma.Cancers · 2022Article
- Clinical Perspectives forMetabolites · 2022Review
- Radiomics Features of the Spleen as Surrogates for CT-Based Lymphoma Diagnosis and Subtype Differentiation.Cancers · 2022Article
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- Response to Induction Therapy in Pediatric Hodgkin's Lymphoma: Performance of First-Order Texture Parameters of CT Images.Journal of the Belgian Society of Radiology · 2022Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesThe purpose of this study was to investigate the ability of computed tomography texture analysis (CTTA) to provide additional prognostic information in patients with Hodgkin's lymphoma (HL) and high-grade non-Hodgkin's lymphoma (NHL).
methodsThis retrospective, pilot-study approved by the IRB comprised 45 lymphoma patients undergoing routine 18F-FDG-PET-CT. Progression-free survival (PFS) was determined from clinical follow-up (mean-duration: 40 months; range: 10-62 months). Non-contrast-enhanced low-dose CT images were submitted to CTTA comprising image filtration to highlight features of different sizes followed by histogram-analysis using kurtosis. Prognostic value of CTTA was compared to PET FDG-uptake value, tumour-stage, tumour-bulk, lymphoma-type, treatment-regime, and interim FDG-PET (iPET) status using Kaplan-Meier analysis. Cox regression analysis determined the independence of significantly prognostic imaging and clinical features.
resultsA total of 27 patients had aggressive NHL and 18 had HL. Mean PFS was 48.5 months. There was no significant difference in pre-treatment CTTA between the lymphoma sub-types. Kaplan-Meier analysis found pre-treatment CTTA (medium feature scale, p=0.010) and iPET status (p<0.001) to be significant predictors of PFS. Cox analysis revealed that an interaction between pre-treatment CTTA and iPET status was the only independent predictor of PFS (HR: 25.5, 95% CI: 5.4-120, p<0.001). Specifically, pre-treatment CTTA risk stratified patients with negative iPET.
conclusionCTTA can potentially provide prognostic information complementary to iPET for patients with HL and aggressive NHL. KEY POINTS: • CT texture-analysis (CTTA) provides prognostic information complementary to interim FDG-PET in Lymphoma. • Pre-treatment CTTA and interim PET status were significant predictors of progression-free survival. • Patients with negative interim PET could be further stratified by pre-treatment CTTA. • Provide precision surveillance where additional imaging reserved for patients at greatest recurrence-risk. • Assists in risk-adapted treatment strategy based on interim PET and CTTA.
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