ReviewPain2016
Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model.
Review in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07363746 (Implementation and Evaluation of a Novel Pain School Intervention Targeting Patients With Chronic Non-cancer Pain as a Tool to Achieve Value in Healthcare.), which is not on this map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementation and Evaluation of a Novel Pain School Intervention Targeting Patients With Chronic Non-cancer Pain as a Tool to Achieve Value in Healthcare.
Who cites it
75 citing papers in PubMed, 151 citations in OpenAlex.
- Trial
- Trial
- Specific versus non-specific hospital-based spine diagnoses in children and adolescents: a nationwide register-based cohort study.Chiropractic & manual therapies · 2026Article
- [Pain management during pregnancy : A balancing act between benefits and risks].Schmerz (Berlin, Germany) · 2026Review
- Experience of Maltreatment Is Associated With Abdominal Pain Intensity and Health-Related Quality of Life in Children With Pain-Predominant Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Article
- Pain Beliefs in the Military: A Qualitative Study Exploring the Perspectives of Instructors Within the Canadian Armed Forces on How Pain Is Addressed in Basic Training and the Broader Military Culture.Canadian journal of pain = Revue canadienne de la douleur · 2026Article
- Epigenetic changes associated with multi-generational trauma: characterization, mechanisms, and therapeutics.Frontiers in psychiatry · 2026Review
- Digital Media Use in Adolescents with Migraine: A Topical Review.Current pain and headache reports · 2025Review
- Informal social support for chronic pain and distress in people with HIV: identifying targets for intervention.medRxiv : the preprint server for health sciences · 2025Article
- Parental opioid prescriptions and the risk of opioid use in adolescents and young adults: The HUNT Study linked with prescription registry data.PLoS medicine · 2025Article
- Characteristics of Children With Persistent Pain and Their Parents in a Tertiary Interdisciplinary Pain Clinic.Paediatric & neonatal pain · 2025Article
- Examining the epigenetic transmission of risk for chronic pain associated with paternal post-traumatic stress disorder: a focus on veteran populations.Translational psychiatry · 2025Review
- Family adversity and co-occurring pain, psychological, and somatic symptom trajectories from late childhood through early adolescence.Social science & medicine (1982) · 2025Article
- Clinical and maternal factors associated with pain and quality of life in children with cerebral palsy.African journal of disability · 2025Article
- Effect of comorbid psychologic and somatic symptom trajectories on early onset substance use among U.S. youth in the ABCD study.Addictive behaviors · 2025Article
- Experimental Pain Sensitivity and Parental Pain Catastrophizing.Children (Basel, Switzerland) · 2024Article
- The Children's Somatic Symptoms Inventory-8: Psychometric Properties of a Brief Measure of Somatic Distress.Children (Basel, Switzerland) · 2024Article
- Social Determinants and Consequences of Pain: Toward Multilevel, Intersectional, and Life Course Perspectives.The journal of pain · 2024Review
- Pain in Adolescence: Maternal and Paternal Factors Affecting Adolescents' Pain in Norway-A Cross-Sectional Study.Children (Basel, Switzerland) · 2023Article
- Pain-coping scale for children and their parents: a cross-sectional study in children with musculoskeletal pain.Pediatric rheumatology online journal · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Offspring of parents with chronic pain are at increased risk for pain and adverse mental and physical health outcomes (Higgins et al, 2015). Although the association between chronic pain in parents and offspring has been established, few studies have addressed why or how this relation occurs. Identifying mechanisms for the transmission of risk that leads to the development of chronic pain in offspring is important for developing preventive interventions targeted to decrease risk for chronic pain and related outcomes (eg, disability and internalizing symptoms). This review presents a conceptual model for the intergenerational transmission of chronic pain from parents to offspring with the goal of setting an agenda for future research and the development of preventive interventions. Our proposed model highlights 5 potential mechanisms for the relation between parental chronic pain and pediatric chronic pain and related adverse outcomes: (1) genetics, (2) alterations in early neurobiological development, (3) pain-specific social learning, (4), general parenting and family health, and (5) exposure to stressful environment. In addition, the model presents 3 potential moderators for the relation between parent and child chronic pain: (1) the presence of chronic pain in a second parent, (2) timing, course, and location of parental chronic pain, and (3) offspring's characteristics (ie, sex, developmental stage, race or ethnicity, and temperament). Such a framework highlights chronic pain as inherently familial and intergenerational, opening up avenues for new models of intervention and prevention that can be family centered and include at-risk children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.