Evidence map›Paper›PMID 27380242›Full record

ArticleHuman genetics2016

Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.

Frank Qian, Ye Feng, Yonglan Zheng, Temidayo O Ogundiran, Oladosu Ojengbede, Wei Zheng, William Blot, Christine B Ambrosone, Esther M John, Leslie Bernstein and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 15 institutions in 3 countries.

Frank QianDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Ye FengDepartment of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Yonglan ZhengDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Temidayo O OgundiranDepartment of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Oladosu OjengbedeCenter for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.
William BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.
Christine B AmbrosoneRoswell Park Cancer Institute, Buffalo, NY, USA.
Esther M JohnCancer Prevention Institute of California, Fremont, CA, USA.
Leslie BernsteinDivision of Cancer Etiology, Department of Population Science, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Jennifer J HuSylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, FL, USA.
Regina G ZieglerEpidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, DC, USA.
Sarah NyanteDepartment of Epidemiology, Gillings School of Global Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Elisa V BanderaRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Sue A InglesDepartment of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Michael F PressDepartment of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Katherine L NathansonDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Anselm HennisChronic Disease Research Centre and Tropical Medicine Research Institute, University of the West Indies, Bridgetown, Barbados.
Barbara NemesureDepartment of Preventive Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA.
Stefan AmbsLaboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA.
Laurence N KolonelEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Olufunmilayo I OlopadeDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Dezheng HuoDepartment of Public Health Sciences, University of Chicago, 5841 S. Maryland Ave., MC 2007, Chicago, IL, 60637, USA. dhuo@health.bsd.uchicago.edu.
University of Chicago · USUniversity of Southern California · USNational Cancer Institute · USUniversity of Ibadan · NGVanderbilt University · USCancer Center of Hawaii · USCancer Prevention Institute of California · USCity of Hope · USRoswell Park Comprehensive Cancer Center · USRutgers, The State University of New Jersey · USState University of New York · USUNC Lineberger Comprehensive Cancer CenterUniversity of Miami · USUniversity of Pennsylvania · USUniversity of the West Indies · BB

Funding

Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
Variation in Hormone and xenobiotic metabolizing enzyme genes and breast cancerP50CA125183 · NCI · UNIVERSITY OF CHICAGO · PI COX, NANCY · 2006 to 2010
$11.3M
Genetics of Breast Cancer in BlacksR01CA089085 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F. · 2002 to 2006
$2.8M
Non-coding RNAs as Prognostic and Diagnostic Markers in Prostate CancerZIABC010886 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBS, STEFAN · 2009 to 2019
$1.6M
Genome-wide association study of breast cancer in the African DiasporaR01CA142996 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F. · 2010 to 2012
$1.5M
NCI NIH HHS P50 CA125183NCI NIH HHS R01 CA089085NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA142996
6 · The paper itself

Abstract

MicroRNAs (miRNA) regulate breast biology by binding to specific RNA sequences, leading to RNA degradation and inhibition of translation of their target genes. While germline genetic variations may disrupt some of these interactions between miRNAs and their targets, studies assessing the relationship between genetic variations in the miRNA network and breast cancer risk are still limited, particularly among women of African ancestry. We systematically put together a list of 822 and 10,468 genetic variants among primary miRNA sequences and 38 genes in the miRNA biogenesis pathway, respectively; and examined their association with breast cancer risk in the ROOT consortium which includes women of African ancestry. Findings were replicated in an independent consortium. Logistic regression was used to estimate the odds ratio (OR) and 95 % confidence intervals (CI). For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 × 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have significant associations in both discovery and validation phases. In a subgroup analysis, two SNPs were associated with risk of estrogen receptor (ER)-negative breast cancer, and three SNPs were associated with risk of ER-positive breast cancer. Several variants in miRNA and miRNA biogenesis pathway genes were associated with breast cancer risk. Risk associations varied by ER status, suggesting potential new mechanisms in etiology.

Indexed as

AdultAgedAged, 80 and overBlack PeopleBreast NeoplasmsDNA-Binding ProteinsEstrogen Receptor alphaFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMicroRNAsMiddle AgedPolymorphism, Single NucleotideRibonuclease IIIDNA-Binding ProteinsDROSHA protein, humanESR1 protein, humanEstrogen Receptor alphaMicroRNAsRibonuclease IIITUT4 protein, human

Identifiers

PMID27380242
PMCPMC5021583
OpenAlexW2475241423

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.