ArticleNeuroradiology2016
Use of 3D pseudo-continuous arterial spin labeling to characterize sex and age differences in cerebral blood flow.
Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Normalization method for relative cerebral blood flow influences sex and cognitive status effects in nondemented older adults.Brain imaging and behavior · 2026Article
- Measuring blood-brain barrier dysfunction: a critical appraisal of fluid biomarkers, in vitro models, in vivo imaging, and post-mortem approaches.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Age-related variations of the hemodynamic response function spatially resolved across human cerebral cortex.Frontiers in aging neuroscience · 2026Article
- The impact of different types of brain injuries on cerebral perfusion in preterm infants: an arterial spin labeling : MRI study.Scientific reports · 2025Article
- Age- and Sex-Specific Cerebral Blood Flow Atlases for Healthy Brain Across the Lifespan.Scientific data · 2025Article
- Regional changes in cerebral perfusion with age when accounting for changes in gray-matter volume.Magnetic resonance in medicine · 2025Article
- Sex differences in age-associated neurological diseases-A roadmap for reliable and high-yield research.Science advances · 2025Review
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- Sex differences in sleep apnea and Alzheimer's Disease: role of cerebrovascular dysfunction.npj women's health · 2025Review
- Can Long-Term Outcomes of Posttraumatic Headache be Predicted?Current pain and headache reports · 2024Review
- A review of multi-modal magnetic resonance imaging studies on perimenopausal brain: a hint towards neural heterogeneity.European radiology · 2023Review
- Race, sex, and mid-life changes in brain health: Cardia MRI substudy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Cerebral perfusion and the risk of cognitive decline and dementia in community dwelling older people.Cerebral circulation - cognition and behavior · 2022Article
- Arterial Spin Labeling Magnetic Resonance Imaging in Healthy Adults: Mathematical Model Fitting to Assess Age-Related Perfusion Pattern.Korean journal of radiology · 2021Article
- Characterizing cerebral hemodynamics across the adult lifespan with arterial spin labeling MRI data from the Human Connectome Project-Aging.NeuroImage · 2021Article
- Article
- Integrative cardiovascular control in women: Regulation of blood pressure, body temperature, and cerebrovascular responsiveness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
- Characterization of Age-Related Differences in the Human Choroid Plexus Volume, Microstructural Integrity, and Blood Perfusion Using Multiparameter Magnetic Resonance Imaging.Frontiers in aging neuroscience · 2021Article
- Observational
- Dynamic cerebral autoregulation is attenuated in young fit women.Physiological reports · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of the present study is to use 3D pseudo-continuous arterial spin labeling (pCASL) to measure changes in normal cerebral blood flow (CBF) values with sex and age.
methodsEighty subjects underwent magnetic resonance imaging study on a 3.0-T scanner. 3D pCASL was used to measure CBF. Estradiol and testosterone levels were also assessed. Based on sex and age, the subjects were divided into four groups for statistical analysis.
resultsCBF was higher in young premenopausal women than in young men (P < 0.01), while there was no difference in CBF between older postmenopausal women and older men. CBF was also significantly decreased in older postmenopausal women compared with young women (P < 0.01), whereas no such age-related effect was present in men.
conclusionThese observations indicate that sex and age differences are important considerations when studying nervous system diseases and that the age range and female-to-male ratio should be considered in the selection of subjects for brain studies in order to eliminate bias. Further, the normal CBF values assessed by pCASL provide a basis for further clinical use of pCASL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.