ArticleCancer causes & control : CCC2016
Inflammatory potential of diet and risk of laryngeal cancer in a case-control study from Italy.
Article in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Meta-analysis of the association between dietary inflammatory index (DII) and upper aerodigestive tract cancer risk.Medicine · 2020Pooled it
- Dietary Inflammatory Index and Site-Specific Cancer Risk: A Systematic Review and Dose-Response Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2018Pooled it
- Pooled it
- Association Between the Dietary Inflammatory Index (DII) and Head and Neck Cancer Incidence-A Narrative Review.Nutrients · 2026Review
- Global, regional and national burden of lip and oral cavity cancer from 1990 to 2021 and projections to 2036.BMC oral health · 2025Article
- The Relationship of Certain Diseases and Dietary Inflammatory Index in Older Adults: A Narrative Review.Current nutrition reports · 2024Review
- Dietary Inflammatory Index and Head and Neck Cancer: A Multicenter Case-Control Study in Iran.Journal of research in health sciences · 2024Article
- Association of SIRT1 single gene nucleotide polymorphisms and serum SIRT1 levels with laryngeal squamous cell carcinoma patient survival rate.Cancer biomarkers : section A of Disease markers · 2022Article
- YY1 Promotes Telomerase Activity and Laryngeal Squamous Cell Carcinoma Progression Through Impairment of GAS5-Mediated p53 Stability.Frontiers in oncology · 2021Article
- Association between dietary inflammatory index and the risk of oral cancer in the southeast of China.European journal of clinical nutrition · 2020Article
- A Higher Dietary Inflammatory Index Score is Associated with a Higher Risk of Incidence and Mortality of Cancer: A Comprehensive Systematic Review and Meta-Analysis.International journal of preventive medicine · 2020Review
- Article
- Physical activity and laryngeal cancer.Annals of translational medicine · 2019Review
- Association between inflammatory potential of diet and risk of lung cancer among smokers in a prospective study in Singapore.European journal of nutrition · 2019Article
- Review
- Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer.International journal of cancer · 2018Article
- Association of proinflammatory diet with low-grade inflammation: results from the Moli-sani study.Nutrition (Burbank, Los Angeles County, Calif.) · 2018Article
- Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults.Oncotarget · 2018Article
- Association between dietary inflammatory index, and cause-specific mortality in the MONICA/KORA Augsburg Cohort Study.European journal of public health · 2018Article
- Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy.International journal of cancer · 2017Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundBesides tobacco and alcohol, diet and inflammation have been suggested to be important risk factors for laryngeal cancer. In this study, we examined the role of diet-associated inflammation, as estimated by dietary inflammatory index (DII) scores, in laryngeal cancer in a multicentre case-control study conducted between 1992 and 2000 in Italy.
methodsThis study included 460 cases with incident, histologically confirmed laryngeal cancer, and 1,088 controls hospitalized for acute non-neoplastic diseases unrelated to tobacco and alcohol consumption. DII scores were computed from a reproducible and valid 78-item food-frequency questionnaire. Logistic regression models controlling for age, sex, study center, education, body mass index, tobacco smoking, alcohol drinking, and non-alcohol energy intake were used to estimate odds ratios (ORs) and the corresponding 95 % confidence intervals (CIs).
resultsSubjects with higher DII scores (i.e., with a more pro-inflammatory diet) had a higher risk of laryngeal cancer. The OR was 3.30 (95 % CI 2.06, 5.28; p for trend <0.0001) for the highest versus the lowest DII quartile. When DII was considered as a continuous variable, the OR was 1.27 (95 % CI 1.15, 1.40) for a one-unit (9 % of the DII range) increase. Stratified analyses produced slightly stronger associations between DII and laryngeal cancer risk among Subjects <60 years old (ORquartile4vs1 = 4.68), overweight subjects (ORQuartile4vs1 = 3.62), and among those with higher education (ORQuartile4vs1 = 3.92). We also observed a strong combined effect of higher DII and tobacco smoking or alcohol consumption on risk of laryngeal cancer. Compared with non-smokers having low DII scores, the OR was 6.64 for smokers with high DII scores. Likewise, compared with non/moderate drinkers with low DII, the OR was 5.82 for heavy drinkers with high DII.
conclusionThese results indicate that a pro-inflammatory diet is associated with increased risk of laryngeal cancer.
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