Evidence map›Paper›PMID 27379917›Full record

ArticleInternational journal of cardiology2016

An injectable capillary-like microstructured alginate hydrogel improves left ventricular function after myocardial infarction in rats.

Domenico G Della Rocca, Bradley J Willenberg, Yanfei Qi, Chelsey S Simmons, Andres Rubiano, Leonardo F Ferreira, Tianyao Huo, John W Petersen, Prashant J Ruchaya, Prateek S Wate and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 41 citations in OpenAlex.

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  13. Alginate and alginate composites for biomedical applications.Asian journal of pharmaceutical sciences · 2021
    Review
  14. Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases.Frontiers in bioengineering and biotechnology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Domenico G Della RoccaDivision of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Bradley J WillenbergDepartment of Materials Science and Engineering, College of Engineering, University of Florida, Gainesville, FL, USA.
Yanfei QiDivision of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Chelsey S SimmonsDepartment of Mechanical and Aerospace Engineering, College of Engineering, University of Florida, Gainesville, FL, USA.
Andres RubianoDepartment of Mechanical and Aerospace Engineering, College of Engineering, University of Florida, Gainesville, FL, USA.
Leonardo F FerreiraDepartment of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, FL, USA.
Tianyao HuoDivision of Biostatistics, Department of Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville, FL, USA.
John W PetersenDivision of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Prashant J RuchayaDepartment of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL, USA.
Prateek S WateDepartment of Materials Science and Engineering, College of Engineering, University of Florida, Gainesville, FL, USA.
Elizabeth A WiseDivision of Hematology & Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Eileen M HandbergDivision of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Christopher R CogleDivision of Hematology & Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Christopher D BatichDepartment of Materials Science and Engineering, College of Engineering, University of Florida, Gainesville, FL, USA.
Barry J ByrneDivision of Cellular and Molecular Therapy, Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.
Carl J PepineDivision of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA. Electronic address: carl.pepine@medicine.ufl.edu.
University of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UFRCC for Cardiovascular Cell Therapy Research NetworkUM1HL087366 · NHLBI · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 2012 to 2018
$4.7M
UFCC for Cardiovascular Cell Therapy Research NetworkU01HL087366 · NHLBI · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 2007 to 2011
$2.6M
NCATS NIH HHS UL1 TR001427NHLBI NIH HHS U01 HL087366NHLBI NIH HHS UM1 HL087366
6 · The paper itself

Abstract

backgroundA new post-myocardial infarction (MI) therapy is injection of high-water-content polymeric biomaterial gels (hydrogels) into damaged myocardium to modulate cardiac negative remodeling and preserve heart function.

methodsWe investigated the therapeutic potential of a novel gelatinized alginate hydrogel with a unique microstructure of uniform capillary-like channels (termed Capgel). Shortly (48h) after induced anterior MI, Sprague Dawley rats received intramyocardial injection of Capgel directly into the antero-septal wall at the infarct border zone (n=12) or no injection (n=10, controls). Echocardiograms were performed at 48h (week 0) and 4weeks (week 4) to evaluate left ventricular function.

resultsEchocardiograms showed 27% improvement of left ventricular systolic function over time with gel injection: fractional shortening increased from 26±3% at week 0 to 33±2% at week 4 (p=0.001). Capgel was present at the injection site after 4weeks, but was minimal at 8weeks. The remaining gel was heavily populated by CD68(+) macrophages with CD206(+) clusters and blood vessels. An in vitro experiment was performed to assess Angiotensin-(1-7) released from Capgel. Angiotensin-(1-7) was released from the Capgel in a sustained manner for 90days.

conclusionsUse of Capgel, a degradable, bioactive hydrogel composed of gelatinized capillary-alginate gel, appears safe for intramyocardial injection, is associated with improved left ventricular function after MI in rats, and may provide a long-term supply of Angiotensin-(1-7).

Indexed as

AlginatesAngiotensin IMyocardial InfarctionPeptide FragmentsAnimalsBiocompatible MaterialsDisease Models, AnimalEchocardiographyGelatinGlucuronic AcidHexuronic AcidsHydrogelsInjections, IntralesionalRatsRats, Sprague-DawleyTreatment OutcomeAlginatesAngiotensin Iangiotensin I (1-7)Biocompatible MaterialsGelatinGlucuronic AcidHexuronic AcidsHydrogelsPeptide FragmentsCapillary-like channelsGelatinized alginate hydrogelMyocardial infarction

Identifiers

PMID27379917
PMCPMC4983460
OpenAlexW2465279685

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.