Trial reportEuropean journal of applied physiology2016
Seven days of high carbohydrate ingestion does not attenuate post-exercise IL-6 and hepcidin levels.
Trial report in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Factors Influencing the Hepcidin Response to Exercise: An Individual Participant Data Meta-analysis.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Association of Daily Dietary Intake and Inflammation Induced by Marathon Race.Mediators of inflammation · 2019Trial
- Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels.Nutrients · 2017Trial
- Effect of 2-h hypoxic exposure on resting hepcidin levels in young adults.Physiological reports · 2025Article
- Review
- Review
- A contemporary understanding of iron metabolism in active premenopausal females.Frontiers in sports and active living · 2022Review
- Review
- Partial sleep deprivation after an acute exercise session does not augment hepcidin levels the following day.Physiological reports · 2020Article
- Iron considerations for the athlete: a narrative review.European journal of applied physiology · 2019Review
- Increased Hepcidin Levels During a Period of High Training Load Do Not Alter Iron Status in Male Elite Junior Rowers.Frontiers in physiology · 2019Article
- Effects of an Acute Exercise Bout on Serum Hepcidin Levels.Nutrients · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis investigation examined if a high carbohydrate (CHO) diet, maintained across a seven-day training period, could attenuate post-exercise interleukin-6 (IL-6) and serum hepcidin levels.
methodsTwelve endurance-trained male athletes completed two seven-day running training blocks whilst consuming either a high (8 g kg(-1)) versus a low (3 g kg(-1)) CHO isoenergetic diet. Each training block consisted of five running sessions performed on days 1, 2, 4, 5, and 7, with the intensity and duration of each session matched between training weeks. Serum levels of Interleukin-6 (IL-6) and hepcidin were measured pre- and either immediately (IL-6) or 3-h (hepcidin) post-exercise on days 1 and 7 of each training week.
resultsDuring each training week, the immediate post-exercise IL-6 and 3-h post-exercise serum hepcidin levels were significantly elevated (both p = 0.001) from pre-exercise on days 1 and 7. These increases were not different between trials.
conclusionsThese results suggest that the ingestion of a high (compared to low) CHO diet over a seven-day training period is ineffective in attenuating post-exercise IL-6 and hepcidin responses. Such results may be due to the modest training load, the increased protein intake in the low-CHO trial, and a 48 h recovery period prior to sample collection on day 7, allowing a full recovery of muscle glycogen status between exercise sessions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.