Observational studyInvestigative radiology2017
Magnetic Resonance Imaging Findings After Percutaneous Irreversible Electroporation of Liver Metastases: A Systematic Longitudinal Study.
Observational study in Investigative radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ablation of hepatic malignant tumors with irreversible electroporation: A systematic review and meta-analysis of outcomes.Oncotarget · 2017Pooled it
- MRI and CT in the follow-up after irreversible electroporation of small renal masses.Diagnostic and interventional radiology (Ankara, Turkey) · 2021Trial
- Liver-tumor mimics as a potential translational framework for planning and testing irreversible electroporation with multiple electrodes.Bioengineering & translational medicine · 2024Article
- Ablative Therapy in Non-HCC Liver Malignancy.Cancers · 2023Review
- Early Differentiation of Irreversible Electroporation Ablation Regions With Radiomics Features of Conventional MRI.Academic radiology · 2022Article
- Evaluation of electroporated area using 2,3,5-triphenyltetrazolium chloride in a potato model.Scientific reports · 2021Article
- Transcatheter intra-arterial perfusion (TRIP)-MRI biomarkers help detect immediate response to irreversible electroporation of rabbit VX2 liver tumor.Magnetic resonance in medicine · 2020Article
- Changes in gadoxetic-acid-enhanced MR imaging during the first year after irreversible electroporation of malignant hepatic tumors.PloS one · 2020Article
- Irreversible Electroporation: Background, Theory, and Review of Recent Developments in Clinical Oncology.Bioelectricity · 2019Review
- Stereotactic Body Radiation Therapy and Ablative Therapies for Solid Tumors: Recent Advances and Clinical Applications.Technology in cancer research & treatment · 2019Article
- 1000 consecutive ablation sessions in the era of computer assisted image guidance - Lessons learned.European journal of radiology open · 2019Article
- Diffusion MRI biomarkers predict the outcome of irreversible electroporation in a pancreatic tumor mouse model.American journal of cancer research · 2018Article
- Uncertainty Quantification in Irreversible Electroporation Simulations.Bioengineering (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to systematically investigate the course of magnetic resonance (MR) signal intensity (SI) changes that occur in noncirrhotic livers after irreversible electroporation (IRE) of liver metastases.
methodsThis study is an institutional review board-approved prospective longitudinal follow-up study on 27 patients with 37 liver metastases who underwent computed tomography-guided percutaneous IRE and a standardized follow-up protocol by serial hepatic MR imaging studies that consisted of a gadobutrol-enhanced dynamic series, axial T2-weighted (T2w) turbo spin echo, and diffusion-weighted imaging (b = 0/50/800), acquired before, within 2, and at 24 hours after IRE; at 1, 2, 4, 6, 8, and 12 weeks after IRE; and every 3 months thereafter for a follow-up of at least 12 months.
resultsThe ablated target lesion remained visible within the ablation zone in 23 (62%) of 37 of cases for a mean time of 21 ± 20 weeks (median, 12 weeks). The ablation zone appeared homogeneously hyperintense on T2w turbo spin echo images on the day of IRE in 37 of 37 cases. By 24 hours after IRE, the ablation zone inverted its SI in 35 of 37 cases to intermediately hypointense, with a rim of T2w bright SI that exhibited arterial phase enhancement; this persisted for 7 ± 5 weeks (median, 4 weeks). The rim resolved in 35 (95%) of 37 cases within 3 months. The ablation zone increased slightly over the first 48 hours, then shrank progressively. Complete healing of the ablation zone was observed in 57% (21/37) after an average of 14 ± 15 (median, 8 weeks).Average apparent diffusion coefficient values of the ablation zone decreased from 0.74 ± 0.36 × 10 mm/s pre-IRE to 0.63 ± 0.27 × 10 mm/s within the first 24 hours (P < 0.05), followed by a progressive normalization to 0.91 ± 0.30 × 10 mm/s at 2 months.
conclusionsKnowledge of the broad spectrum of MR imaging findings after IRE is important to avoid diagnostic errors in the follow-up of patients after IRE.
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