ReviewFrontiers in nutrition2016
Thiamine Deficiency in Tropical Pediatrics: New Insights into a Neglected but Vital Metabolic Challenge.
Review in Frontiers in nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 84 citations in OpenAlex.
- An Endemic Region of Thiamine-Responsive Megaloblastic Anemia Caused by anInternational journal of molecular sciences · 2026Article
- Fulminant Thiamine Deficiency in An Infant: Authors' Reply.Indian journal of pediatrics · 2026Article
- Fedratinib in chronic kidney disease: antifibrotic potential and renal safety signals from integrated network toxicology and pharmacovigilance.Renal failure · 2025Article
- Fulminant Thiamine Deficiency in An Infant.Indian journal of pediatrics · 2025Article
- Thiamine Deficiency Secondary to Pain-Induced Oral Aversion.Clinical pediatrics · 2025Article
- Thiamine deficiency secondary to intestinal surgery leading to shoshin beriberi and Wernicke encephalopathy: a case report.Frontiers in pediatrics · 2025Article
- Micronutrient status in children aged 6-59 months with severe wasting and/or nutritional edema: implications for nutritional rehabilitation formulations.Nutrition reviews · 2025Review
- Thiamine: An indispensable regulator of paediatric neuro-cardiovascular health and diseases.European journal of pediatrics · 2024Review
- The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults.Nutrients · 2024Review
- OsTH1 is a key player in thiamin biosynthesis in rice.Scientific reports · 2024Article
- Assessment of Erythrocyte Transketolase, Whole Blood Thiamine Diphosphate, and Human Milk Thiamine Concentrations to Identify Infants and Young Children Responding Favorably to Therapeutic Thiamine Administration: Findings from the Lao Thiamine Study, a Prospective Cohort Study.Current developments in nutrition · 2024Article
- A Predictive Model for Thiamine Responsive Disorders Among Infants and Young Children: Results from a Prospective Cohort Study in Lao People's Democratic Republic.The Journal of pediatrics · 2024Article
- Thiamine deficiency-related neuropathy: A reversible entity from an endemic area.European journal of neurology · 2024Observational
- Cerebral Metabolic Crisis in Pediatric Cerebral Malaria.Journal of pediatric intensive care · 2023Article
- Thiamine deficiency in pregnancy and lactation: implications and present perspectives.Frontiers in nutrition · 2023Review
- Optimal Nutrition Parameters for Neonates and Infants with Congenital Heart Disease.Nutrients · 2022Review
- Beriberi Neuropathy Mimicking Guillian-Barre Syndrome in a Teenager With Food Restriction: A Case Report.Cureus · 2022Article
- Thiamine as a Possible Neuroprotective Strategy in Neonatal Hypoxic-Ischemic Encephalopathy.Antioxidants (Basel, Switzerland) · 2021Review
- Thiamine supplementation holds neurocognitive benefits for breastfed infants during the first year of life.Annals of the New York Academy of Sciences · 2021Article
- Thiamine fortification strategies in low- and middle-income settings: a review.Annals of the New York Academy of Sciences · 2021Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans, thiamine is a micronutrient prone to depletion that may result in severe clinical abnormalities. This narrative review summarizes current knowledge on thiamine deficiency (TD) and bridges the gap between pathophysiology and clinical presentation by integrating thiamine metabolism at subcellular level with its function to vital organs. The broad clinical spectrum of TD is outlined, with emphasis on conditions encountered in tropical pediatric practice. In particular, TD is associated with type B lactic acidosis and classic forms of beriberi in children, but it is often unrecognized. Other severe acute conditions are associated with hypermetabolism, inducing a functional TD. The crucial role of thiamine in infant cognitive development is also highlighted in this review, along with analysis of the potential impact of TD in refeeding syndrome during severe acute malnutrition (SAM). This review aims to increase clinical awareness of TD in tropical settings where access to diagnostic tests is poor, and advocates for an early therapeutic thiamine challenge in resource-limited settings. Moreover, it provides evidence for thiamine as treatment in critical conditions requiring metabolic resuscitation, and gives rationale to the consideration of increased thiamine supplementation in therapeutic foods for malnourished children.
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