ArticleJournal of ophthalmology2016
Assessment of Corneal Epithelial Thickness in Asymmetric Keratoconic Eyes and Normal Eyes Using Fourier Domain Optical Coherence Tomography.
Article in Journal of ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- The role of corneal epithelial thickness parameters with different degrees of keratoconus in the diagnosis of keratoconus.Molecular vision · 2026Article
- Corneal epithelial aberrations: a novel diagnostic tool for keratoconus and forme fruste keratoconus.Eye and vision (London, England) · 2025Article
- Diagnostic performance of corneal epithelium- and Bowman's layer thickness mapping in patients with unilateral Keratoconus.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- The role of corneal epithelial thickness map in detecting early keratoconus.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Detecting Keratoconus in Adolescents with Anterior Segment Optical Coherence Tomography.Journal of ophthalmology · 2024Article
- Corneal Epithelial Thickness Mapping: A Major Review.Journal of ophthalmology · 2024Review
- Diagnostic Accuracy of Corneal and Epithelial Thickness Map Parameters to Detect Keratoconus and Suspect Keratoconus.Journal of ophthalmology · 2023Article
- Corneal Epithelial Mapping Characteristics in Normal Eyes Using Anterior Segment Spectral Domain Optical Coherence Tomography.Translational vision science & technology · 2022Article
- A Review of Imaging Biomarkers of the Ocular Surface.Eye & contact lens · 2020Review
- Epithelial map-guided anterior stromal micropuncture for the treatment of recurrent corneal erosion syndrome.International ophthalmology · 2019Article
- Advances in Biomechanical Parameters for Screening of Refractive Surgery Candidates: A Review of the Literature, Part III.Medical hypothesis, discovery & innovation ophthalmology journal · 2019Review
- Comparison of Corneal Epithelial Thickness Map Measured by Spectral Domain Optical Coherence Tomography in Healthy, Subclinical and Early Keratoconus Subjects.Medical hypothesis, discovery & innovation ophthalmology journal · 2019Article
- Optical coherence tomography for ocular surface and corneal diseases: a review.Eye and vision (London, England) · 2018Review
- Ultrahigh-resolution OCT imaging of the human cornea.Biomedical optics express · 2017Article
- Distribution Pattern of Total Corneal Thickness in Keratoconus versus Normal Eyes Using an Optical Coherence Tomography.Journal of current ophthalmologyArticle
- Impact of contact lens wear on epithelial alterations in keratoconus.Journal of optometryArticle
- A review of corneal imaging methods for the early diagnosis of pre-clinical Keratoconus.Journal of optometryReview
- Role of corneal epithelial mapping, Corvis biomechanical index, and artificial intelligence-based tomographic biomechanical index in diagnosing spectrum of keratoconus.Oman journal of ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose. To compare the characteristics of asymmetric keratoconic eyes and normal eyes by Fourier domain optical coherence tomography (OCT) corneal mapping. Methods. Retrospective corneal and epithelial thickness OCT data for 74 patients were compared in three groups of eyes: keratoconic (n = 22) and normal fellow eyes (n = 22) in patients with asymmetric keratoconus and normal eyes (n = 104) in healthy subjects. Areas under the curve (AUC) of receiver operator characteristic (ROC) curves for each variable were compared across groups to indicate their discrimination capacity. Results. Three variables were found to differ significantly between fellow eyes and normal eyes (all p < 0.05): minimum corneal thickness, thinnest corneal point, and central corneal thickness. These variables combined showed a high discrimination power to differentiate fellow eyes from normal eyes indicated by an AUC of 0.840 (95% CI: 0.762-0.918). Conclusions. Our findings indicate that topographically normal fellow eyes in patients with very asymmetric keratoconus differ from the eyes of healthy individuals in terms of their corneal epithelial and pachymetry maps. This type of information could be useful for an early diagnosis of keratoconus in topographically normal eyes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.