ArticleFrontiers in plant science2016
Polyamine Resistance Is Increased by Mutations in a Nitrate Transporter Gene NRT1.3 (AtNPF6.4) in Arabidopsis thaliana.
Article in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Functional characterization of NRT1/PTR FAMILY transporters: looking for a needle in a haystack.The New phytologist · 2026Review
- Evolutionary trajectory of the NPF6.3(NRT1.1/CHL1)-centered nitrate signaling regulatory network in plant roots.BMC plant biology · 2025Article
- The Genome of Lolium multiflorum Reveals the Genetic Architecture of Paraquat Resistance.Molecular ecology · 2025Article
- Functional and Molecular Characterization of Plant Nitrate Transporters Belonging to NPF (NRT1/PTR) 6 Subfamily.International journal of molecular sciences · 2024Review
- Identification of growth regulators using cross-species network analysis in plants.Plant physiology · 2022Article
- Nitrate Uptake and Use Efficiency: Pros and Cons of Chloride Interference in the Vegetable Crops.Frontiers in plant science · 2022Review
- Flexible response and rapid recovery strategies of the plateau forageFrontiers in plant science · 2022Article
- Transcriptome and Small RNA Sequencing Reveal the Mechanisms Regulating Harvest Index inFrontiers in plant science · 2022Article
- Responses of Polyamine-Metabolic Genes to Polyamines and Plant Stress Hormones in Arabidopsis Seedlings.Cells · 2021Article
- Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery.Developmental cell · 2021Article
- Short-Term Exposure to High Atmospheric Vapor Pressure Deficit (VPD) Severely Impacts Durum Wheat Carbon and Nitrogen Metabolism in the Absence of Edaphic Water Stress.Plants (Basel, Switzerland) · 2021Article
- Lipid kinases PIP5K7 and PIP5K9 are required for polyamine-triggered KThe Plant journal : for cell and molecular biology · 2020Article
- The Consequences of a Disruption in Cyto-Nuclear Coadaptation on the Molecular Response to a Nitrate Starvation in Arabidopsis.Plants (Basel, Switzerland) · 2020Article
- The Interplay among Polyamines and Nitrogen in Plant Stress Responses.Plants (Basel, Switzerland) · 2019Review
- Tissue and nitrogen-linked expression profiles of ammonium and nitrate transporters in maize.BMC plant biology · 2019Article
- Extracellular Spermine Triggers a Rapid Intracellular Phosphatidic Acid Response in Arabidopsis, Involving PLDδ Activation and Stimulating Ion Flux.Frontiers in plant science · 2019Article
- The Expected and Unexpected Roles of Nitrate Transporters in Plant Abiotic Stress Resistance and Their Regulation.International journal of molecular sciences · 2018Review
- Nitrate Accumulation and Expression Patterns of Genes Involved in Nitrate Transport and Assimilation in Spinach.Molecules (Basel, Switzerland) · 2018Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyamines are small basic compounds present in all living organisms and act in a variety of biological processes. However, the mechanism of polyamine sensing, signaling and response in relation to other metabolic pathways remains to be fully addressed in plant cells. As one approach, we isolated Arabidopsis mutants that show increased resistance to spermine in terms of chlorosis. We show here that two of the mutants have a point mutation in a nitrate transporter gene of the NRT1/PTR family (NPF), NRT1.3 (AtNPF6.4). These mutants also exhibit increased resistance to putrescine and spermidine while loss-of-function mutants of the two closest homologs of NRT1.3, root-specific NRT1.1 (AtNPF6.3) and petiole-specific NRT1.4 (AtNPF6.2), were shown to have a normal sensitivity to polyamines. When the GUS reporter gene was expressed under the control of the NRT1.3 promoter, GUS staining was observed in leaf mesophyll cells and stem cortex cells but not in the epidermis, suggesting that NRT1.3 specifically functions in parenchymal tissues. We further found that the aerial part of the mutant seedling has normal levels of polyamines but shows reduced uptake of norspermidine compared with the wild type. These results suggest that polyamine transport or metabolism is associated with nitrate transport in the parenchymal tissue of the shoot.
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