ArticleFrontiers in microbiology2016
ICEApl1, an Integrative Conjugative Element Related to ICEHin1056, Identified in the Pig Pathogen Actinobacillus pleuropneumoniae.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- ISAntibiotics (Basel, Switzerland) · 2025Article
- Identification of novel small RNAs in extracellular vesicles produced byFrontiers in microbiology · 2023Article
- Methodology for laboratory-based antimicrobial resistance surveillance in animals.Veterinary world · 2022Review
- Complete genome forMicrobial genomics · 2021Article
- Comparative Genome Sequence Analysis ofFrontiers in microbiology · 2021Article
- Molecular Characterization of a Novel Integrative Conjugative Element ICEFrontiers in microbiology · 2020Article
- Present and Future Surveillance of Antimicrobial Resistance in Animals: Principles and Practices.Microbiology spectrum · 2018Review
- A Novel Glaesserella sp. Isolated from Pigs with Severe Respiratory Infections Has a Mosaic Genome with Virulence Factors Putatively Acquired by Horizontal Transfer.Applied and environmental microbiology · 2018Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Evidence of Illegitimate Recombination Between TwoFrontiers in microbiology · 2018Article
- Characterization of the Actinobacillus pleuropneumoniae SXT-related integrative and conjugative element ICEApl2 and analysis of the encoded FloR protein: hydrophobic residues in transmembrane domains contribute dynamically to florfenicol and chloramphenicol efflux.The Journal of antimicrobial chemotherapy · 2018Article
- Comparative Genomics of the First and Complete Genome of "International journal of genomics · 2018Article
- Whole Genome Sequencing for Surveillance of Antimicrobial Resistance inFrontiers in microbiology · 2017Article
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
ICEApl1 was identified in the whole genome sequence of MIDG2331, a tetracycline-resistant (MIC = 8 mg/L) serovar 8 clinical isolate of Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia. PCR amplification of virB4, one of the core genes involved in conjugation, was used to identify other A. pleuropneumoniae isolates potentially carrying ICEApl1. MICs for tetracycline were determined for virB4 positive isolates, and shotgun whole genome sequence analysis was used to confirm presence of the complete ICEApl1. The sequence of ICEApl1 is 56083 bp long and contains 67 genes including a Tn10 element encoding tetracycline resistance. Comparative sequence analysis was performed with similar integrative conjugative elements (ICEs) found in other members of the Pasteurellaceae. ICEApl1 is most similar to the 59393 bp ICEHin1056, from Haemophilus influenzae strain 1056. Although initially identified only in serovar 8 isolates of A. pleuropneumoniae (31 from the UK and 1 from Cyprus), conjugal transfer of ICEApl1 to representative isolates of other serovars was confirmed. All isolates carrying ICEApl1 had a MIC for tetracycline of 8 mg/L. This is, to our knowledge, the first description of an ICE in A. pleuropneumoniae, and the first report of a member of the ICEHin1056 subfamily in a non-human pathogen. ICEApl1 confers resistance to tetracycline, currently one of the more commonly used antibiotics for treatment and control of porcine pleuropneumonia.
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