ArticleFrontiers in pharmacology2016
Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection.
Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
- Biological activities (antimicrobial, anti-inflammatory, anti-coronavirus (229E)) and chemical composition of some essential oils.Scientific reports · 2026Article
- Immunomodulatory Effects of Medicinal Plants.Advances in experimental medicine and biology · 2026Review
- Chitosan-Based Nanoencapsulation of Mānuka Oil for Periodontal Treatment.International journal of molecular sciences · 2025Review
- Menthol and Its Derivatives: Exploring the Medical Application Potential.Engineering in life sciences · 2025Review
- Investigating the Health Potential ofPharmaceuticals (Basel, Switzerland) · 2025Review
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- Phytochemistry and Biological Activities ofInternational journal of molecular sciences · 2025Article
- Cerium Oxide Nanoparticles (CeOPlants (Basel, Switzerland) · 2024Article
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- Menthone Exerts its Antimicrobial Activity Against Methicillin ResistantDrug design, development and therapy · 2023Article
- Chemical Profiling and Biological Activities ofPlants (Basel, Switzerland) · 2022Article
- Menthol carbonates as potent antiparasitic agents: synthesis and in vitro studies along with computer-aided approaches.BMC complementary medicine and therapies · 2022Article
- Menthone Inhalation Alleviates Local and Systemic Allergic Inflammation in Ovalbumin-Sensitized and Challenged Asthmatic Mice.International journal of molecular sciences · 2022Article
- Protective effects of menthol against sepsis-induced hepatic injury: Role of mediators of hepatic inflammation, apoptosis, and regeneration.Frontiers in pharmacology · 2022Article
- The Severity of Acute Kidney and Lung Injuries Induced by Cecal Ligation and Puncture Is Attenuated by Menthol: Role of Proliferating Cell Nuclear Antigen and Apoptotic Markers.Frontiers in medicine · 2022Article
- Schiff bases complexed with iron and their relation with the life cycle and infection byFrontiers in immunology · 2022Article
- Synthesis, Antifungal Activity, 3D-QSAR, and Molecular Docking Study of Novel Menthol-Derived 1,2,4-Triazole-thioether Compounds.Molecules (Basel, Switzerland) · 2021Article
- Rapid Screening of Glucocorticoid Receptor (GR) Effectors Using Cortisol-Detecting Sensor Cells.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis is a parasitic disease caused by several species of trematode worms and it is believed that more than 261 million people are affected worldwide. New drug development has become essential because there is a risk of the parasite becoming resistant to Praziquantel, the only drug available for this infection. This study evaluated parasitological, immunological and histological parameters in mice infected with Schistosoma mansoni and treated with an herbal commercial medicine. This drug consists of menthol (30-55%) and menthone (14-32%). A 60 day treatment regimen with the herbal medicine decreased the number of S. mansoni eggs in the feces, liver, and intestine and reduced the number of hepatic granulomas. We observed a reduction of 84% in blood eosinophilia and a decrease in the IL-4 and IL-10 blood levels after treatment. Therefore, we propose that schistosomiasis treatment with this herbal medicine for 60 days has an immunomodulatory and anti-inflammatory action in this animal model for schistosomiasis thus contributing to the decrease in physio pathological effects caused by S. mansoni infection.
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