ReviewFrontiers in aging neuroscience2016
Pharmacotherapy of Pain in the Older Population: The Place of Opioids.
Review in Frontiers in aging neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- Opioids to Treat Chronic Pain in the Older Adult: A Clinical Consensus to Guarantee Safety and Avoid Adverse Events.Drugs & aging · 2026Review
- Opioid prescribing to older cancer survivors: a retrospective claims-based characterization of prescriber specialties.Journal of cancer survivorship : research and practice · 2025Article
- Differences in opioid use and overdose among younger and older justice-impacted adults.Health & justice · 2025Article
- Short-term mortality after opioid initiation among opioid-naïve and non-naïve patients with dementia: a retrospective cohort study.BMC medicine · 2025Article
- Low Back Pain Presentation and Management at the Emergency Department: Differences Between Older Adults Residing in the Community and Aged Care Homes.Journal of evaluation in clinical practice · 2025Observational
- Development of a set of indicators for the quality of chronic pain management in Chinese community-dwelling older adults: a Delphi study.BMC geriatrics · 2024Article
- Opioids in geriatric units in 14 Belgian hospitals: prevalence, dosage and associated factors.Annals of medicine · 2024Article
- Article
- Opioid metabolism and drug-drug interaction in cancer.The oncologist · 2024Review
- Patterns and predictors of opioid dispensing among older cancer patients from 2008 to 2015.Cancer medicine · 2024Article
- Short-Term Opioid Treatment of Acute Locomotor Pain in Older Adults: Comparison of Effectiveness and Safety between Tramadol and Oxycodone: A Randomized Trial.Geriatrics (Basel, Switzerland) · 2024Article
- Hydrocodone, Oxycodone, and Morphine Metabolism and Drug-Drug Interactions.The Journal of pharmacology and experimental therapeutics · 2023Review
- Over the Counter Pain Medications Used by Adults: A Need for Pharmacist Intervention.International journal of environmental research and public health · 2023Article
- Pain management for people with dementia: a cross-setting systematic review and meta-ethnography.British journal of pain · 2023Article
- Age-related changes in peripheral nociceptor function.Neuropharmacology · 2022Article
- Population Pharmacokinetic Model for Tramadol and O-desmethyltramadol in Older Patients.European journal of drug metabolism and pharmacokinetics · 2022Article
- Article
- Attitudes and Beliefs of College Students towards Pain Management Modalities: Theory of Planned Behavior Approach.Chronic pain & management · 2022Article
- Better Executive Functions Are Associated With More Efficient Cognitive Pain Modulation in Older Adults: An fMRI Study.Frontiers in aging neuroscience · 2022Article
- Population pharmacokinetic model of subcutaneous fentanyl in older acute care patients.European journal of clinical pharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is a common symptom in older people. It is possible that pain is underreported in older persons due to an incorrect belief that it is an inevitable part of aging. Opioid analgesics are potent medications, with confirmed efficacy for the treatment of moderate to severe pain. These drugs are commonly used in older persons. However, there is insufficient evidence regarding safety of opioids in older patients. One of the reasons for this is the lack of randomized, controlled clinical trials. People of advanced age often have comorbidites and use other prescription drugs, as well as over-the-counter (OTC) compounds, thus making them more suceptible to the risk of interactions with opioids. Significant pharmacokinetic and pharmacodynamic changes that occur with advancing age increase the risk of adverse effects of opioids. There are also some discrepancies between guidelines, which recommend the use of lower doses of opioids in older patients, and the findings in the literature which suggest that pain is often undertreated in this age group. It seems that there are significant variations in the tolerability of different opioid analgesics in older people. Morphine, fentanyl, oxycodone, and buprenorphine are still the preferred evidence-based choices for add-on opioid therapy for these patients. However, the safety and efficacy of other opioids in older patients, especially if comorbidities and polypharmacy are present, is still questionable. This review addresses the most important aspects of the use of opioids in older persons, focusing on pharmacokinetics, pharmacodynamics, adverse effects, and interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.