ArticleFrontiers in human neuroscience2016
Doubt in the Insula: Risk Processing in Obsessive-Compulsive Disorder.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Common and Distinct Neural Mechanisms Underlying Risk Seeking and Risk Aversion: Evidence From the Neuroimaging Meta-Analysis.Human brain mapping · 2025Pooled it
- Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula.Neuromodulation : journal of the International Neuromodulation Society · 2019Trial
- Male Sapap3 knockout mice show threat bias under conflict during platform-mediated avoidance task: effects of extinction with response prevention and implications for obsessive compulsive disorder.Translational psychiatry · 2026Article
- A novel approach-avoidance task to study decision making under outcome uncertainty.Psychonomic bulletin & review · 2026Article
- Brain Activation During Virtual Reality Symptom Provocation in Obsessive-Compulsive Disorder: Proof-of-Concept Study.JMIR XR and spatial computing · 2024Article
- Abnormal resting-state functional connectivity of the insula in medication-free patients with obsessive-compulsive disorder.BMC psychiatry · 2022Article
- Ventral Striatal Activation During Reward Anticipation of Different Reward Probabilities in Adolescents and Adults.Frontiers in human neuroscience · 2021Article
- Behavioral indicators of succeeding and failing under higher-challenge compulsion-like alcohol drinking in rat.Behavioural brain research · 2020Article
- Prolonged avoidance training exacerbates OCD-like behaviors in a rodent model.Translational psychiatry · 2020Article
- Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- A structural MRI study of excoriation (skin-picking) disorder and its relationship to clinical severity.Psychiatry research. Neuroimaging · 2017Article
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7 authors.
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Abstract
Extensive cleaning or checking of patients with obsessive-compulsive disorder (OCD) are often interpreted as strategies to avoid harm and as an expression of the widespread belief that OCD patients are more risk-averse. However, despite its clinical significance, the neural basis of risk attitude in OCD is unknown. Here, we investigated neural activity during risk processing using functional magnetic resonance imaging and simultaneously assessed risk attitude using a separate behavioral paradigm in OCD patients with different symptoms versus healthy controls (HCs). We found opposite insula responses to high versus low risk in OCD patients compared to HCs: a positive correlation between insula activity and risk-aversion in patients versus a negative correlation in controls. Although OCD patients overall were not more risk-averse than controls, there were differences between subgroups of OCD patients: patients with doubt/checking symptoms were more risk-averse than other patients. Taken together, OCD patients show a reversed pattern of risk processing by the insula compared to HCs. Moreover, the data suggest that increased activation of the insula signals an abnormal urge to avoid risks in the subpopulation of OCD patients with doubt and checking symptoms. These results indicate a role for the insula in excessive risk-avoidance relevant to OCD.
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