ArticleJournal of labelled compounds & radiopharmaceuticals2016
Fully automated synthesis of [(18) F]fluoro-dihydrotestosterone ([(18) F]FDHT) using the FlexLab module.
Article in Journal of labelled compounds & radiopharmaceuticals, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- SyntheticRSC medicinal chemistry · 2024Review
- Imaging Androgen Receptors in Breast Cancer withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Fluorine-18 Labeled Fluorofuranylnorprogesterone ([Molecules (Basel, Switzerland) · 2019Article
- Ring opening of epoxides with [Chemical communications (Cambridge, England) · 2019Article
- Production of diverse PET probes with limited resources: 24Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Evaluation of Castration-Resistant Prostate Cancer with Androgen Receptor-Axis Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Article
- [Neuro-oncology advancesArticle
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Authors and funding
7 authors.
Funding
Abstract
Imaging of androgen receptor expression in prostate cancer using F-18 FDHT is becoming increasingly popular. With the radiolabelling precursor now commercially available, developing a fully automated synthesis of [(18) F] FDHT is important. We have fully automated the synthesis of F-18 FDHT using the iPhase FlexLab module using only commercially available components. Total synthesis time was 90 min, radiochemical yields were 25-33% (n = 11). Radiochemical purity of the final formulation was > 99% and specific activity was > 18.5 GBq/µmol for all batches. This method can be up-scaled as desired, thus making it possible to study multiple patients in a day. Furthermore, our procedure uses 4 mg of precursor only and is therefore cost-effective. The synthesis has now been validated at Austin Health and is currently used for [(18) F]FDHT studies in patients. We believe that this method can easily adapted by other modules to further widen the availability of [(18) F]FDHT.
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