Evidence map›Paper›PMID 27377754›Full record

ArticleBMC psychiatry2016

No association between the rs10503253 polymorphism in the CSMD1 gene and schizophrenia in a Han Chinese population.

Yansong Liu, Zaohuo Cheng, Jun Wang, Chunhui Jin, Jianmin Yuan, Guoqiang Wang, Fuquan Zhang, Xudong Zhao

Open access · goldAbstract read
In one paragraph

Article in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yansong LiuDepartment of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China.
Zaohuo ChengWuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
Jun WangWuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
Chunhui JinWuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
Jianmin YuanWuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
Guoqiang WangWuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China.
Fuquan ZhangWuxi Mental Health Center, Wuxi, 214151, Jiangsu Province, China. zhangfq@njmu.edu.cn.
Xudong ZhaoDepartment of Psychosomatic Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China. zhaoxd@tongji.edu.cn.
Jiangxi Mental Health Center · CNShanghai East Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSchizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Recent genome-wide association studies have identified a single-nucleotide polymorphism (SNP; rs10503253) in the CUB and SUSHI multiple domains 1 (CSMD1) gene as a risk factor for SCZ. In this study, we investigated whether the rs10503253 in CSMD1 contributes to the risk of SCZ in a Han Chinese population.

methodsWe conducted a case-control study in a population from eastern China, involving 1378 SCZ patients and 1091 unrelated healthy controls, using the ligase detection reaction-polymerase chain reaction method to genotype the rs10503253 polymorphism in the CSMD1 gene.

resultsNo significant association was found between the SCZ patients and controls for any allele or genotype frequency of the SNP rs10503253 (all P > 0.05).

conclusionsOur findings do not support an association between CSMD1 rs10503253 and SCZ in a Han Chinese population.

Indexed as

AdultAllelesAsian PeopleCase-Control StudiesChinaFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMembrane ProteinsMiddle AgedPolymorphism, Single NucleotideRisk FactorsSchizophreniaTumor Suppressor ProteinsCSMD1 protein, humanMembrane ProteinsTumor Suppressor ProteinsCSMD1rs10503253Schizophrenia

Identifiers

PMID27377754
PMCPMC4932686
OpenAlexW2460710499

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.