ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Acid Sensing Ion Channels (ASICs) in the brain: emerging roles in physiology and pathology.Pflugers Archiv : European journal of physiology · 2026Review
- [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- 4-(Azolyl)-Benzamidines as a Novel Chemotype for ASIC1a Inhibitors.International journal of molecular sciences · 2024Article
- Triggering of Major Brain Disorders by Protons and ATP: The Role of ASICs and P2X Receptors.Neuroscience bulletin · 2023Review
- Acetazolamide: Old drug, new evidence?Epilepsia open · 2022Review
- Acid-Sensing Ion Channel 2: Function and Modulation.Membranes · 2022Review
- Ketogenic Diet Alleviates Hippocampal Neurodegeneration Possibly via ASIC1a and the Mitochondria-Mediated Apoptotic Pathway in a Rat Model of Temporal Lobe Epilepsy.Neuropsychiatric disease and treatment · 2022Article
- Finishing stationary cycling too early after anterior cruciate ligament reconstruction is likely to lead to higher failure.BMC sports science, medicine & rehabilitation · 2021Article
- Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain.Current neuropharmacology · 2021Review
- [Acid-sensing ion channels differentially affect ictal-like and non-ictal-like epileptic activities of mouse hippocampal pyramidal neurons in acidotic extracellular pH].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory NeuronsFrontiers in neurology · 2019Article
- CB2R induces a protective response for epileptic seizure via the PI3K 110α-AKT signaling pathway.Experimental and therapeutic medicine · 2018Article
- Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function.Neurochemical research · 2018Article
- The synaptic action of Degenerin/Epithelial sodium channels.Channels (Austin, Tex.) · 2018Review
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy.Scientific reports · 2017Article
- TheThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Calcium and ATP control multiple vital functions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acid-sensing ion channels (ASICs) play an important role in numerous functions in the central and peripheral nervous systems ranging from memory and emotions to pain. The data correspond to a recent notion that each neuron and many glial cells of the mammalian brain express at least one member of the ASIC family. However, the mechanisms underlying the involvement of ASICs in neuronal activity are poorly understood. However, there are two exceptions, namely, the straightforward role of ASICs in proton-based synaptic transmission in certain brain areas and the role of the Ca(2+)-permeable ASIC1a subtype in ischaemic cell death. Using a novel orthosteric ASIC antagonist, we have found that ASICs specifically control the frequency of spontaneous inhibitory synaptic activity in the hippocampus. Inhibition of ASICs leads to a strong increase in the frequency of spontaneous inhibitory postsynaptic currents. This effect is presynaptic because it is fully reproducible in single synaptic boutons attached to isolated hippocampal neurons. In concert with this observation, inhibition of the ASIC current diminishes epileptic discharges in a low Mg(2+) model of epilepsy in hippocampal slices and significantly reduces kainate-induced discharges in the hippocampus in vivo Our results reveal a significant novel role for ASICs.This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'.
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