Evidence map›Paper›PMID 27377696›Full record

ArticleThe Journal of investigative dermatology2016

Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes.

Yang Yu, Jackson Champer, George W Agak, Stephanie Kao, Robert L Modlin, Jenny Kim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.

  1. Using probiotics to treat acne vulgaris: systematic review.Archives of dermatological research · 2024
    Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. IntradiscalJOR spine · 2026
    Article
  7. Article
  8. Article
  9. Is There a Place for Biologics in Acne?American journal of clinical dermatology · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Skin microbiome and dermatologic disorders.The Journal of clinical investigation · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. The Central Roles of Keratinocytes in Coordinating Skin Immunity.The Journal of investigative dermatology · 2024
    Review
  18. Review
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yang YuDivision of Dermatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Jackson ChamperDivision of Dermatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
George W AgakDivision of Dermatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Stephanie KaoDivision of Dermatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Robert L ModlinDivision of Dermatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA.
Jenny KimDivision of Dermatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA. Electronic address: jekim@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Innate Immunity in Acne VulgarisR01AR053542 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIM, JENNY J · 2009 to 2013
$1.3M
Dermatology Scientist Training ProgramT32AR058921 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2010 to 2014
$877k
NIAMS NIH HHS R01 AR053542NIAMS NIH HHS T32 AR058921
6 · The paper itself

Abstract

Propionibacterium acnes is a skin commensal bacterium that contributes to the development of acne vulgaris and other infections. Recent work revealed that P. acnes clinical isolates can be classified into distinct phylotypes, several of which have associations with healthy skin or acne. We sought to determine if these phylotypes induce different immunological responses and express protein factors that may contribute to their disease associations. We found that acne-associated P. acnes phylotypes induced 2- to 3-fold higher levels of IFN-γ and IL-17 in peripheral blood mononuclear cells compared with healthy phylotypes. On the other hand, P. acnes phylotypes associated with healthy skin induced 2- to 4-fold higher levels of IL-10. Comparative proteomic analysis of P. acnes phylotypes revealed a differential expression of several proteins, including an adhesion protein that was expressed at least 10-fold higher in acne-associated phylotypes and a cell surface hydrolase expressed in all phylotypes except those associated with healthy skin. Taken together, our data provide insight into how specific P. acnes phylotypes influence immune responses and the pathogenesis of acne.

Indexed as

Immunity, CellularAcne VulgarisAdolescentAdultChildCytokinesFemaleGram-Positive Bacterial InfectionsHumansMalePropionibacterium acnesProteomeProteomicsYoung AdultCytokinesProteome

Identifiers

PMID27377696
PMCPMC8295477
OpenAlexW2471866068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.