Evidence map›Paper›PMID 27377691›Full record

ReviewNeuroscience and biobehavioral reviews2016

Neurobiological signatures associated with alcohol and drug use in the human adolescent brain.

Marisa M Silveri, Alecia D Dager, Julia E Cohen-Gilbert, Jennifer T Sneider

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Concurrent and long-term effects of early pubertal timing on alcohol, cigarette, and cannabis use from adolescence to adulthood.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marisa M SilveriNeurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: msilveri@mclean.harvard.edu.
Alecia D DagerOlin Neuropsychiatry Research Center, Hartford, CT, USA; Department of Psychiatry, Yale University, New Haven, CT, USA.
Julia E Cohen-GilbertNeurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Jennifer T SneiderNeurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

Funding

Consequences of Adolescent Alcohol Use on Brain DevelopmentR01AA022493 · NIAAA · MCLEAN HOSPITAL · PI SILVERI, MARISA M · 2014 to 2018
$2.5M
Neurobiological consequences of binge alcohol consumption in young adultsR01AA018153 · NIAAA · MCLEAN HOSPITAL · PI SILVERI, MARISA M · 2010 to 2014
$1.6M
Neurochemical and Functional Correlates of Memory in Emerging Adult Marijuana UsersK01DA038207 · NIDA · YALE UNIVERSITY · PI DAGER, ALECIA DENISE · 2015 to 2018
$659k
Neural and cognitive factors predicting adverse outcomes in college drinkers.K01AA022392 · NIAAA · MCLEAN HOSPITAL · PI COHEN-GILBERT, JULIA ELIZABETH · 2014 to 2018
$657k
NIAAA NIH HHS K01 AA022392NIAAA NIH HHS R01 AA018153NIAAA NIH HHS R01 AA022493NIDA NIH HHS K01 DA038207
6 · The paper itself

Abstract

Magnetic resonance (MR) techniques provide opportunities to non-invasively characterize neurobiological milestones of adolescent brain development. Juxtaposed to the critical finalization of brain development is initiation of alcohol and substance use, and increased frequency and quantity of use, patterns that can lead to abuse and addiction. This review provides a comprehensive overview of existing MR studies of adolescent alcohol and drug users. The most common alterations reported across substance used and MR modalities are in the frontal lobe (63% of published studies). This is not surprising, given that this is the last region to reach neurobiological adulthood. Comparatively, evidence is less consistent regarding alterations in regions that mature earlier (e.g., amygdala, hippocampus), however newer techniques now permit investigations beyond regional approaches that are uncovering network-level vulnerabilities. Regardless of whether neurobiological signatures exist prior to the initiation of use, this body of work provides important direction for ongoing prospective investigations of adolescent brain development, and the significant impact of alcohol and substance use on the brain during the second decade of life.

Indexed as

BrainAdolescentEthanolHumansIllicit DrugsMagnetic Resonance ImagingSubstance-Related DisordersEthanolIllicit DrugsAddictionAdolescenceAlcoholDevelopmentDTIfMRIFrontal lobeHippocampusImpulsivityMarijuanaMRIMRSNicotineResting stateReward sensitivitySubstance abuse

Identifiers

PMID27377691
PMCPMC5494836

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.