Observational studyThe Laryngoscope2017
Low 22-item sinonasal outcome test scores in chronic rhinosinusitis: Why do patients seek treatment?
Observational study in The Laryngoscope, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Long-acting implantable corticosteroid matrix for chronic rhinosinusitis: Results of LANTERN Phase 2 randomized controlled study.International forum of allergy & rhinology · 2022Trial
- Analysis of factors associated with electing endoscopic sinus surgery.The Laryngoscope · 2018Trial
- Association Between Subjective Symptom Severity and Radiologic Involvement in CRSwNP Patients Using SNOT-22 and Lund-Mackay Scores.Iranian journal of otorhinolaryngology · 2026Article
- Psychometric Validation and Meaningful Change Thresholds of the New Nasal Polyposis Symptom Diary.The Annals of otology, rhinology, and laryngology · 2023Article
- Evaluation of Improvement in Chronic Rhinosinusitis After Endoscopic Sinus Surgery Using Sino-Nasal Outcome Test-22 (SNOT22) Symptom Score.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- The incidence and impact of anosmia on daily life after COVID-19 infection: A cross-sectional study in a tertiary center in Saudi Arabia.Saudi medical journal · 2022Article
- Development of Sinonasal Outcome Test (SNOT-22) Domains in Chronic Rhinosinusitis With Nasal Polyps.The Laryngoscope · 2022Article
- Microbiomics of irrigation with xylitol orLaryngoscope investigative otolaryngology · 2021Article
- Ivacaftor improves rhinologic, psychologic, and sleep-related quality of life in G551D cystic fibrosis patients.International forum of allergy & rhinology · 2019Article
- Improved perioperative quality of life in endoscopic sinus surgery by application of enhanced recovery after surgery.Therapeutics and clinical risk management · 2019Article
- What drives productivity loss in chronic rhinosinusitis? A SNOT-22 subdomain analysis.The Laryngoscope · 2018Observational
- Investigating the minimal clinically important difference for SNOT-22 symptom domains in surgically managed chronic rhinosinusitis.International forum of allergy & rhinology · 2017Observational
- THE 2017 13International forum of allergy & rhinology · 2017Article
- Use of the long-term quality of life assessment in the decision to indicate surgery in patients with chronic rhinosinusitis.Brazilian journal of otorhinolaryngologyObservational
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectives/hypothesisPatients with chronic rhinosinusitis (CRS) who experience minimal reductions in quality of life (QoL) may present for treatment despite QoL scores comparable to controls without CRS. This study seeks to identify cofactors influencing patients with CRS and low 22-item Sinonasal Outcome Test (SNOT-22) scores to seek care. STUDY
designProspective, multicenter, observational cohort.
methodsPatients with CRS were enrolled between April 2011 and September 2015. Patients with sinonasal mucocele or unilateral sinus opacification were excluded. Control subjects without CRS were enrolled for comparison. Low-SNOT CRS was defined as a SNOT-22 score < 20.
resultsA total of 774 subjects (low-SNOT CRS, n = 38; high-SNOT CRS, SNOT-22 ≥ 20, n = 641; controls without CRS, n = 95) were enrolled. Low SNOT scores were identified in 6% of subjects with CRS. After adjustment, low-SNOT CRS and control groups without CRS reported similar baseline average SNOT-22 total scores (P = .879). Unexpectedly, compared to controls, low-SNOT CRS patients had significantly better average psychological (2.1 ± 2.3 vs. 5.8 ± 6.0; P = .030) and sleep dysfunction (2.7 ± 3.4 vs. 6.0 ± 5.2; P = .016) scores. Fourteen of 38 (37%) low-SNOT patients elected to undergo endoscopic sinus surgery (ESS), with a significantly lower likelihood of reporting a minimal clinically important difference (MCID) when compared to high-SNOT patients (43% vs. 82%; P < .001) after a mean follow-up of ∼15 months.
conclusionsLow-SNOT CRS patients represent an outlier population for which measures of QoL fail to identify factors influencing the decision to seek treatment. Low-SNOT CRS patients electing ESS have a decreased likelihood of reporting MCIDs following ESS. Further study is required to identify novel factors associated with treatment-seeking behavior in this population. LEVEL OF EVIDENCE: 3B Laryngoscope, 127:22-28, 2017.
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