ArticleBrain, behavior, and immunity2016
Sex differences in the association between stressor-evoked interleukin-6 reactivity and C-reactive protein.
Article in Brain, behavior, and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The effects of acute psychological stress on circulating and stimulated inflammatory markers: A systematic review and meta-analysis.Brain, behavior, and immunity · 2017Pooled it
- The effect of beta-adrenergic blockade on inflammatory and cardiovascular responses to acute mental stress.Brain, behavior, and immunity · 2018Trial
- Inflammatory and Cardiovascular Responses to Active and Passive Acute Psychological Stress.Biopsychosocial science and medicineTrial
- Stress-induced IL-6 response patterns amplify the link between daily negative affect and later depressive symptoms during bereavement.Brain, behavior, and immunity · 2026Article
- Prognostic Value of the Lactate-to-Albumin and C-Reactive Protein-to-Albumin Ratios in COVID-19-Associated ARDS.Journal of clinical medicine · 2026Article
- Investigating psychosocial factors and systemic inflammation using dried blood spots: a scoping review.Social psychiatry and psychiatric epidemiology · 2025Article
- Article
- Interleukin-6 modulates endoplasmic reticulum stress signaling and mitochondrial protein complexes in the kidney following acute exhaustive exercise.Cell stress & chaperones · 2025Article
- Spousal bereavement enhances proinflammatory cytokine production to acute, psychological stress.Psychoneuroendocrinology · 2025Article
- IL-6 Expression and the Confidence Interval-Based Estimation of Relevance (CIBER) Help Identify Persistent Inflammation and Cognitive Parameters of Executive Dysfunction in the Withdrawal Phase of Male Polydrug Abusers.Healthcare (Basel, Switzerland) · 2025Article
- Stressor-Evoked Brain Activity, Cardiovascular Reactivity, and Subclinical Atherosclerosis in Midlife Adults.Journal of the American Heart Association · 2025Article
- Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults.Journal of behavioral medicine · 2024Article
- IL-6 after wake-up in human males: Exposure to red versus blue light and the interplay with cortisol.Brain, behavior, & immunity - health · 2024Article
- Growth differentiation factor 15 and malnutrition in older adults.The journal of nutrition, health & aging · 2024Article
- Stressor-evoked brain activity, cardiovascular reactivity, and subclinical atherosclerosis in midlife adults.medRxiv : the preprint server for health sciences · 2024Article
- Sex differences in a double-blind randomized clinical trial with minocycline in treatment-resistant depressed patients: CRP and IL-6 as sex-specific predictors of treatment response.Brain, behavior, & immunity - health · 2022Article
- The inflammatory immune system after wake up in healthy male individuals: A highly standardized and controlled study.Brain, behavior, & immunity - health · 2022Article
- The influence of inflammation on cardiovascular disease in women.Frontiers in global women's health · 2022Review
- Association between occupational or environmental noise exposure and renal function among middle-aged and older Korean adults: a cross-sectional study.Scientific reports · 2021Article
- The Changes inJournal of molecular neuroscience : MN · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Individuals differ consistently in the magnitude of their inflammatory responses to acute stressors, with females often showing larger responses than males. While the clinical significance of these individual differences remains unclear, it may be that greater inflammatory responses relate to increased systemic inflammation and thereby risk for chronic inflammatory disease. Here, we examined whether acute stressor-evoked interleukin (IL)-6 responses associate with resting levels of C-reactive protein (CRP), a marker of systemic inflammation, and whether this association differs by sex. Subjects were 57 healthy midlife adults (30-51years; 33% female; 68% white). Blood was drawn before and 30-min after two mental stress tasks: a multisource interference task and a Stroop color word task. Hierarchical regressions controlling for age, sex, race, and BMI tested whether stressor-evoked IL-6 responses were associated with resting CRP and whether this association differed by sex. Results indicated that sex and stressor-evoked IL-6 responses interacted to predict CRP (ΔR
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.