Evidence map›Paper›PMID 27377520›Full record

ArticleThe American journal of gastroenterology2016

Long-Term Clinical Outcomes of Rectal Neuroendocrine Tumors According to the Pathologic Status After Initial Endoscopic Resection: A KASID Multicenter Study.

Chang Mo Moon, Kyu Chan Huh, Sung-Ae Jung, Dong Il Park, Won Hee Kim, Hye Mi Jung, Seong-Joon Koh, Jin-Oh Kim, Yunho Jung, Kyeong Ok Kim and 6 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 15 institutions in 1 country.

Chang Mo MoonDepartment of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea.
Kyu Chan HuhDepartment of Internal Medicine, Konyang University College of Medicine, Konyang University Hospital, Daejeon, South Korea.
Sung-Ae JungDepartment of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea.
Dong Il ParkDepartment of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Won Hee KimDigestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, South Korea.
Hye Mi JungDepartment of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Seong-Joon KohDepartment of Internal Medicine, Seoul National University College of Medicine, Boramae Medical Center, Seoul, South Korea.
Jin-Oh KimDepartment of Internal Medicine, Soonchunhyang University College of Medicine, Seoul Hospital, Seoul, South Korea.
Yunho JungDepartment of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, South Korea.
Kyeong Ok KimDepartment of Internal Medicine, Yeungnam University College of Medicine, Daegu, South Korea.
Jong Wook KimDepartment of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, South Korea.
Dong-Hoon YangDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jeong Eun ShinDepartment of Internal Medicine, Dankook University College of Medicine, Cheonan, South Korea.
Sung Jae ShinDepartment of Internal Medicine, Ajou University School of Medicine, Suwon, South Korea.
Eun Soo KimDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea.
Young-Eun JooDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Ewha Womans University · KRAjou University · KRCHA University · KRChonnam National University · KRDankook University · KRInje University Ilsan Paik Hospital · KRKangbuk Samsung Hospital · KRKeimyung University · KRKonyang University Hospital · KRSamsung Medical Center · KRSNUH SMG-SNU Boramae Medical Center · KRSoonchunhyang University · KRSoonchunhyang University Hospital Seoul · KRUlsan College · KRYeungnam University College

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWith advances in diagnostic endoscopy, the detection of rectal neuroendocrine tumors (NETs) has increased. However, clinical outcomes, especially after endoscopic treatment, are still unclear. The aim of this study was to determine the long-term clinical outcomes of endoscopically resected rectal NETs according to the pathologic status after initial resection.

methodsIn this large, multicenter, retrospective cohort study, we analyzed the medical records of patients who underwent endoscopic resection of rectal NETs and were followed for ≥24 months at 16 university hospitals. The outcomes of interest were local or distant recurrence and metachronous lesions.

resultsOn the pathologic assessment of 407 patients, the resection margin status was positive in 76 (18.7%) and indeterminate in 72 (17.7%) patients. Patients whose rectal NETs were diagnosed or suspected as NETs before resection showed a much higher complete resection rate than those whose tumors were resected as polyps and then diagnosed (P<0.001). Fourteen patients received salvage treatment at 1.9±2.8 months after initial treatment. During a median follow-up period of 45.0 months, local recurrence occurred in 3 (0.74%) patients, but there was no recurrence in the lymph nodes or distant organs. Metachronous rectal NETs were diagnosed in 3 (0.74%) patients. According to the pathologic status after initial resection, local recurrence and metachronous lesions occurred in 1 (0.4%) and 2 (0.8%) patients, respectively, in the pathologic tumor-free group, whereas they occurred in 2 (1.4%) and 1 (0.7%) patients, respectively, in the indeterminate group.

conclusionsConsidering the long-term prognosis including that for recurrences or metachronous lesions, endoscopic resection is an efficient and a safe modality for the treatment of rectal NETs. This treatment may result in favorable clinical outcomes in patients with tumors of indeterminate pathology, as well as in pathologic tumor-free cases after initial resection.

Indexed as

AdolescentAdultAgedAged, 80 and overColonoscopyEndoscopic Mucosal ResectionFemaleHumansIntestinal PolypsLongitudinal StudiesMaleMiddle AgedNeoplasm Recurrence, LocalNeuroendocrine TumorsPrognosisRectal Neoplasms

Identifiers

PMID27377520
OpenAlexW2466391519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.