Evidence map›Paper›PMID 27377469›Full record

ArticleMolecular carcinogenesis2017

CD24 is a genetic modifier for risk and progression of prostate cancer.

Yifan Zhang, Bingjin Li, Xingyi Zhang, Guru P Sonpavde, Kenneth Jiao, Andrea Zhang, Guangxin Zhang, Mei Sun, Chengjing Chu, Feng Li and 3 more

Open access · greenAbstract read
In one paragraph

Article in Molecular carcinogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yifan ZhangDepartmentof Thoracic Surgery, The Second Hospital of Jilin University, Changchun, P.R. China.
Bingjin LiJilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, P.R. China.
Xingyi ZhangDepartmentof Thoracic Surgery, The Second Hospital of Jilin University, Changchun, P.R. China.
Guru P SonpavdeDepartment of Internal Medicine, Section of Medical Oncology, University of Alabama at Birmingham, Birmingham, Alabama.
Kenneth JiaoDepartment of Genetics, University of Alabama at Birmingham, Birmingham, Alabama.
Andrea ZhangDepartment of Genetics, University of Alabama at Birmingham, Birmingham, Alabama.
Guangxin ZhangDepartmentof Thoracic Surgery, The Second Hospital of Jilin University, Changchun, P.R. China.
Mei SunDepartment of Pathology, The Second Hospital of Jilin University, Changchun, P.R. China.
Chengjing ChuDepartment of Health and Social Science, Guangdong Medical College, Dongguan, P.R. China.
Feng LiAnshan Normal University Affiliated Health School, Anshan, P.R. China.
Lizhong WangDepartment of Genetics, University of Alabama at Birmingham, Birmingham, Alabama.
Ranji CuiJilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun, P.R. China.
Runhua LiuDepartment of Genetics, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · USSecond Affiliated Hospital of Jilin University · CNAnshan Normal University · CNGuangdong Medical College · CN

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
TRAINING AND CAREER DEVELOPMENTU54CA118948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI UPENDER MANNE · 2005 to 2026
$26.6M
Research Training & Career Development ProgramU54CA118638 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI Desiree Avia Rivers · 2005 to 2026
$22.7M
Research Education CoreU54CA118623 · NCI · TUSKEGEE UNIVERSITY · PI Vivian L Carter, TIMOTHY TURNER · 2005 to 2026
$20.2M
INFRASTRUCTURE IIG12MD007585 · NIMHD · TUSKEGEE UNIVERSITY · PI YATES, CLAYTON · 2012 to 2016
$4.6M
Roles of Semaphorin Signaling in Breast Cancer Racial DisparitiesR21CA199586 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JIAO, KAI, WANG, LIZHONG · 2015 to 2016
$352k
MicroRNAs for monitoring tumor progression and predicting response to therapyR21CA179282 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, LIZHONG · 2014 to 2015
$352k
NCATS NIH HHS UL1 TR001417NCI NIH HHS P30 CA013148NCI NIH HHS R21 CA179282NCI NIH HHS R21 CA199586NCI NIH HHS U54 CA118623NCI NIH HHS U54 CA118638NCI NIH HHS U54 CA118948NIMHD NIH HHS G12 MD007585
6 · The paper itself

Abstract

CD24 plays an oncogenic role in the onset and progression of various human cancers, including prostate cancer. In the present study, we identified two linkage disequilibrium blocks with four recombination hotspot motifs in human CD24 locus. To elucidate whether genetic variants of CD24 are associated with susceptibility to prostate cancer and its disease status, we conducted a case-control association study with two P170 C/T and P-534 A/C polymorphisms of CD24 in 590 patients with prostate cancer and 590 healthy controls. A significant increased risk of prostate cancer was found in men with the P170

Indexed as

Polymorphism, GeneticAgedAged, 80 and overAllelesCase-Control StudiesCD24 AntigenDisease ProgressionGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseGenotypeHumansLinkage DisequilibriumMaleMiddle AgedOdds RatioPolymorphism, Restriction Fragment LengthCD24 AntigenCD24polymorphismprostate cancertumor progression

Identifiers

PMID27377469
PMCPMC5205546
OpenAlexW2469021419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.