Evidence map›Paper›PMID 27377247›Full record

ReviewThe Journal of cell biology2016

Chromatin assembly: Journey to the CENter of the chromosome.

Chin-Chi Chen, Barbara G Mellone

Abstract readReview
In one paragraph

Review in The Journal of cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chin-Chi ChenDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269.
Barbara G MelloneDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269 Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269 barbara.mellone@uconn.edu.

Funding

A novel animal model approach to investigate neocentromere formation and inactivaR01GM108829 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI MELLONE, BARBARA · 2014 to 2018
$1.5M
NIGMS NIH HHS R01 GM108829
6 · The paper itself

Abstract

All eukaryotic genomes are packaged into basic units of DNA wrapped around histone proteins called nucleosomes. The ability of histones to specify a variety of epigenetic states at defined chromatin domains is essential for cell survival. The most distinctive type of chromatin is found at centromeres, which are marked by the centromere-specific histone H3 variant CENP-A. Many of the factors that regulate CENP-A chromatin have been identified; however, our understanding of the mechanisms of centromeric nucleosome assembly, maintenance, and reorganization remains limited. This review discusses recent insights into these processes and draws parallels between centromeric and noncentromeric chromatin assembly mechanisms.

Indexed as

Chromatin Assembly and DisassemblyAnimalsAutoantigensCentromereCentromere Protein AChromosomal Proteins, Non-HistoneChromosomesDNA ReplicationHumansTranscription, GeneticAutoantigensCENPA protein, humanCentromere Protein AChromosomal Proteins, Non-Histone

Identifiers

PMID27377247
PMCPMC4932374

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.