ArticlePhotosynthesis research2017
The plastoquinol-plastoquinone exchange mechanism in photosystem II: insight from molecular dynamics simulations.
Article in Photosynthesis research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- The Effective Force Constant Approach of Protein Flexibility Applied to Selected Photosynthetic Protein Complexes.Molecules (Basel, Switzerland) · 2026Review
- Review
- Chemistry of Lipoquinones: Properties, Synthesis, and Membrane Location of Ubiquinones, Plastoquinones, and Menaquinones.International journal of molecular sciences · 2022Review
- Conformational Changes and H-Bond Rearrangements during Quinone Release in Photosystem II.Biochemistry · 2022Article
- Investigation of Photosystem II Functional Size in Higher Plants under Physiological and Stress Conditions Using Radiation Target Analysis and Sucrose Gradient Ultracentrifugation.Molecules (Basel, Switzerland) · 2022Article
- Binding Properties of Photosynthetic Herbicides with the QPlants (Basel, Switzerland) · 2021Article
- Dynamics Properties of Photosynthetic Microorganisms Probed by Incoherent Neutron Scattering.Biophysical journal · 2019Article
- In silico assessment of new progesterone receptor inhibitors using molecular dynamics: a new insight into breast cancer treatment.Journal of molecular modeling · 2018Article
- Photosystem-II D1 protein mutants of Chlamydomonas reinhardtii in relation to metabolic rewiring and remodelling of H-bond network at QScientific reports · 2018Article
- Exchange pathways of plastoquinone and plastoquinol in the photosystem II complex.Nature communications · 2017Article
- Redesign of the Chlamydomonas reinhardtii QPhysiologia plantarumArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the photosystem II (PSII) of oxygenic photosynthetic organisms, the reaction center (RC) core mediates the light-induced electron transfer leading to water splitting and production of reduced plastoquinone molecules. The reduction of plastoquinone to plastoquinol lowers PSII affinity for the latter and leads to its release. However, little is known about the role of protein dynamics in this process. Here, molecular dynamics simulations of the complete PSII complex embedded in a lipid bilayer have been used to investigate the plastoquinol release mechanism. A distinct dynamic behavior of PSII in the presence of plastoquinol is observed which, coupled to changes in charge distribution and electrostatic interactions, causes disruption of the interactions seen in the PSII-plastoquinone complex and leads to the "squeezing out" of plastoquinol from the binding pocket. Displacement of plastoquinol closes the second water channel, recently described in a 2.9 Å resolution PSII structure (Guskov et al. in Nat Struct Mol Biol 16:334-342, 2009), allowing to rule out the proposed "alternating" mechanism of plastoquinol-plastoquinone exchange, while giving support to the "single-channel" one. The performed simulations indicated a pivotal role of D
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