Evidence map›Paper›PMID 27376696›Full record

ArticleAtherosclerosis2016

Self-reported depression in psoriasis is associated with subclinical vascular diseases.

Tsion M Aberra, Aditya A Joshi, Joseph B Lerman, Justin A Rodante, Asha K Dahiya, Heather L Teague, Qimin Ng, Joanna I Silverman, Alexander V Sorokin, Taufiq Salahuddin and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. What Factors Influence on Dermatology-Related Life Quality of Psoriasis Patients in South Korea?International journal of environmental research and public health · 2021
    Article
  5. Observational
  6. Observational
  7. Psoriasis and Co-morbidity.Acta dermato-venereologica · 2020
    Review
  8. Review
  9. Article
  10. Article
  11. Cardiometabolic Comorbidities in Psoriasis and Psoriatic Arthritis.International journal of molecular sciences · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Tsion M AberraNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Aditya A JoshiNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Joseph B LermanNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Justin A RodanteNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Asha K DahiyaNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Heather L TeagueNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Qimin NgNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Joanna I SilvermanNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Alexander V SorokinNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Taufiq SalahuddinNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Benjamin N LockshinDermAssociates, Silver Spring, MD, USA.
Mark A AhlmanMolecular Biomedical Imaging Laboratory, National Institutes of Health, Bethesda, MD, USA.
Martin P PlayfordNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Marcus Y ChenNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Joel M GelfandDepartment of Dermatology, University of Pennsylvania, Philadelphia, PA, USA; The Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA.
Nehal N MehtaNational Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: nehal.mehta@nih.gov.
National Heart Lung and Blood Institute · USNational Institutes of Health · USUniversity of Pennsylvania · US

Funding

Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic disease (PACI) InitiativeZIAHL006193 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2014 to 2023
$25.0M
Cardiovascular CT Clinical ResearchZIAHL006220 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHEN, MARCUS · 2017 to 2025
$22.5M
A trial to determine the effect of psoriasis treatment on cardiometabolic diseaseR01HL111293 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GELFAND, JOEL M · 2012 to 2017
$3.8M
Psoriasis and the Risk of DiabetesK24AR064310 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI GELFAND, JOEL M · 2013 to 2017
$870k
Intramural NIH HHS Z99 CL999999Intramural NIH HHS ZIA HL006193NHLBI NIH HHS R01 HL111293NIAMS NIH HHS K24 AR064310
6 · The paper itself

Abstract

BACKGROUND AND

aimsPsoriasis is a chronic inflammatory disorder associated with vascular inflammation, measured by 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT), and an increased risk of myocardial infarction. Patients with psoriasis are also more likely to suffer from comorbid depression. Whether depression accelerates the development of subclinical atherosclerosis in psoriasis is unknown.

methodsPatients were selected from within a larger psoriasis cohort. Those who reported a history of depression (N = 36) on survey were matched by age and gender to patients who reported no history of psychiatric illness (N = 36). Target-to-background ratio from FDG PET/CT was used to assess aortic vascular inflammation and coronary CT angiography scans were analyzed to determine coronary plaque burden. Multivariable linear regression was performed to understand the effect of self-reported depression on vascular inflammation and coronary plaque burden after adjustment for Framingham risk (standardized β reported).

resultsIn unadjusted analyses, vascular inflammation and coronary plaque burden were significantly increased in patients with self-reported depression as compared to patients with psoriasis alone. After adjustment for Framingham Risk Score, vascular inflammation (β = 0.26, p = 0.02), total plaque burden (β = 0.17, p = 0.03), and non-calcified burden (β = 0.17, p = 0.03) were associated with self-reported depression.

conclusionsSelf-reported depression in psoriasis is associated with increased vascular inflammation and coronary plaque burden. Depression may play an important role in promoting subclinical atherosclerosis beyond traditional cardiovascular risk factors.

Indexed as

Self ReportCardiovascular DiseasesCohort StudiesComorbidityComputed Tomography AngiographyCoronary VesselsDepressionFemaleGlomerular Filtration RateHumansInflammationMaleMiddle AgedMultivariate AnalysisPositron Emission Tomography Computed TomographyPsoriasisAnxietyDepressionInflammationPsoriasisSubclinical cardiovascular disease

Identifiers

PMID27376696
PMCPMC5305805
OpenAlexW2394997630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.