ArticleNature materials2016
Mechanical plasticity of cells.
Article in Nature materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- A statistical damage model for coupled mechano-electrophysiological axonal injury.PLoS computational biology · 2026Article
- Next-Generation Hydrogels for Biliary Organoid Engineering.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- Dynamic substrate topographies drive actin- and vimentin-mediated nuclear mechanoprotection events in human fibroblasts.BMC biology · 2025Article
- Structural response of microtubule and actin cytoskeletons to direct intracellular load.The Journal of cell biology · 2025Article
- Characteristic frequencies of localized stress relaxation in scaling-law rheology of living cells.Biophysical journal · 2025Article
- Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics.Nature physics · 2025Article
- Advances in mechanotransduction and sonobiology: effects of audible acoustic waves and low-vibration stimulations on mammalian cells.Biophysical reviews · 2024Review
- Deformation under flow and morphological recovery of cancer cells.Lab on a chip · 2024Article
- Beyond stiffness: Multiscale viscoelastic features as biomechanical markers for assessing cell types and states.Biophysical journal · 2024Article
- An emerging role for tissue plasticity in developmental precision.Biochemical Society transactions · 2024Review
- Multiplexed Single-Cell Rheology Probing Using Surface Acoustic Waves.Small science · 2024Article
- Active viscoelastic models for cell and tissue mechanics.Royal Society open science · 2024Article
- SEMAPL bioengineering · 2023Article
- A mechanism-based theory of cellular and tissue plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Micro-/nanoscale robotics for chemical and biological sensing.Lab on a chip · 2023Review
- Mechanosensitive ion channels in apoptosis and ferroptosis: focusing on the role of Piezo1.BMB reports · 2023Review
- Application of sequential cyclic compression on cancer cells in a flexible microdevice.PloS one · 2023Article
- Microdevice-based mechanical compression on living cells.iScience · 2022Review
- A GENERAL RETURN-MAPPING FRAMEWORK FOR FRACTIONAL VISCO-ELASTO-PLASTICITY.Fractal and fractional · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under mechanical loading, most living cells show a viscoelastic deformation that follows a power law in time. After removal of the mechanical load, the cell shape recovers only incompletely to its original undeformed configuration. Here, we show that incomplete shape recovery is due to an additive plastic deformation that displays the same power-law dynamics as the fully reversible viscoelastic deformation response. Moreover, the plastic deformation is a constant fraction of the total cell deformation and originates from bond ruptures within the cytoskeleton. A simple extension of the prevailing viscoelastic power-law response theory with a plastic element correctly predicts the cell behaviour under cyclic loading. Our findings show that plastic energy dissipation during cell deformation is tightly linked to elastic cytoskeletal stresses, which suggests the existence of an adaptive mechanism that protects the cell against mechanical damage.
Identifiers
27376682What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.