Evidence map›Paper›PMID 27376567›Full record

ArticleInternational journal of cardiology2016

Stroke symptoms and risk for incident coronary heart disease in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.

Lisandro D Colantonio, Christopher M Gamboa, Dawn O Kleindorfer, April P Carson, Virginia J Howard, Paul Muntner, Mary Cushman, George Howard, Monika M Safford

Open access · greenAbstract read
In one paragraph

Article in International journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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  6. Atrial Fibrillation and Stroke Symptoms in the REGARDS Study.Journal of the American Heart Association · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lisandro D ColantonioDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States.
Christopher M GamboaDepartment of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Dawn O KleindorferDepartment of Neurology, School of Medicine, University of Cincinnati, Cincinnati, OH, United States.
April P CarsonDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States.
Virginia J HowardDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States.
Paul MuntnerDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States.
Mary CushmanDepartment of Medicine, School of Medicine, University of Vermont, Burlington, VT, United States.
George HowardDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States.
Monika M SaffordDepartment of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States; General Internal Medicine, Weill Cornell Medicine, New York, NY, United States. Electronic address: mms9024@med.cornell.edu.
University of Alabama at Birmingham · USUniversity of Cincinnati · USUniversity of Vermont · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
REGARDS - MI StudyR01HL080477 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEVITAN, EMILY B, SAFFORD, MONIKA M · 2006 to 2020
$11.6M
Building Capacity for Cardiometabolic Outcomes ResearchK24HL111154 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAFFORD, MONIKA M · 2012 to 2015
$556k
NHLBI NIH HHS K24 HL111154NHLBI NIH HHS R01 HL080477NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundMany adults without cerebrovascular disease report a history of stroke symptoms, which is associated with higher risk for stroke. Because stroke and coronary heart disease (CHD) share many risk factors, we examined the association between a history of stroke symptoms and incident CHD.

methodsWe analyzed data from 8999 black and 12,499 white REasons for Geographic And Racial Differences in Stroke (REGARDS) study participants without a prior myocardial infarction, stroke or transitory ischemic attack enrolled in 2003-2007 (total participants=21,498, all ≥45years of age). A history of stroke symptoms (i.e., unilateral weakness, unilateral numbness, full-field vision loss, half-field vision loss, understanding problems and communication problems) was assessed at baseline using the Questionnaire for Verifying Stroke-Free Status. Participants were followed for incident CHD and CHD death through December 2011.

resultsOverall, 3432 (16.0%) participants reported a history of stroke symptoms (1771 [19.7%] blacks and 1661 [13.3%] whites). There were 701 incident CHD events including 209 CHD deaths over a median follow-up of 5.8years. After adjustment for CHD risk factors, hazard ratios (95% confidence interval [95% CI]) for incident CHD associated with reporting any versus no stroke symptoms were 1.26 (1.04-1.51) in the overall population, 1.28 (0.99-1.65) among blacks and 1.23 (0.94-1.61) among whites. Multivariable-adjusted hazard ratios (95% CI) for CHD death associated with any versus no stroke symptoms were 1.50 (1.10-2.06) overall, 1.58 (1.07-2.32) among blacks and 1.41 (0.82-2.43) among whites.

conclusionA history of stroke symptoms is associated with a higher incidence of CHD among black and white adults.

Indexed as

Coronary Artery DiseaseStrokeAgedBlack or African AmericanBlack PeopleFemaleHumansIncidenceMaleMedical History TakingMiddle AgedProportional Hazards ModelsRisk AssessmentRisk FactorsSymptom AssessmentUnited StatesCerebrovascular disordersCoronary diseaseEpidemiologyRisk factors

Identifiers

PMID27376567
PMCPMC4983497
OpenAlexW2422950694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.