ReviewNatural product reports2016
Modern mass spectrometry for synthetic biology and structure-based discovery of natural products.
Review in Natural product reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Dual-functionMicrobiology spectrum · 2026Article
- Aurantiosides A-D: New Furofuran Lignan Glucosides with Neuroprotective Activity fromACS omega · 2025Article
- Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.Angewandte Chemie (International ed. in English) · 2025Review
- Discovery of Streptomyces species CS-62, a novel producer of the Acinetobacter baumannii selective antibiotic factumycin.Journal of industrial microbiology & biotechnology · 2024Article
- Discovering New Natural Products Using Metabolomics-Based Approaches.Advances in experimental medicine and biology · 2023Article
- Mass Spectroscopy as an Analytical Tool to Harness the Production of Secondary Plant Metabolites: The Way Forward for Drug Discovery.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Rapid Mining of NovelMarine drugs · 2022Article
- Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy.Journal of hematology & oncology · 2022Review
- Article
- Sesquiterpene Lactams and Lactones With Antioxidant Potentials FromFrontiers in nutrition · 2022Article
- MetEx, a Metabolomics Explorer Application for Natural Product Discovery.ACS chemical biology · 2021Article
- Natural-Product-Based Solutions for Tropical Infectious Diseases.Clinical microbiology reviews · 2021Review
- Synthetic Natural Product Inspired Cyclic Peptides.ACS chemical biology · 2021Article
- Recent developments in self-resistance gene directed natural product discovery.Natural product reports · 2020Review
- Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2.Natural product reports · 2019Review
- Staring into the void: demystifying microbial metabolomics.FEMS microbiology letters · 2019Article
- Dereplication of Components Coupled with HPLC-qTOF-MS in the Active Fraction ofMolecules (Basel, Switzerland) · 2019Article
- Differentiation of Ficus deltoidea varieties and chemical marker determination by UHPLC-TOFMS metabolomics for establishing quality control criteria of this popular Malaysian medicinal herb.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Breaking the silence: new strategies for discovering novel natural products.Current opinion in biotechnology · 2017Review
- Using MS-FINDER for identifying 19 natural products in the CASMI 2016 contest.Phytochemistry letters · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Covering: up to 2016In this highlight, we describe the current landscape for dereplication and discovery of natural products based on the measurement of the intact mass by LC-MS. Often it is assumed that because better mass accuracy (provided by higher resolution mass spectrometers) is necessary for absolute chemical formula determination (≤1 part-per-million), that it is also necessary for dereplication of natural products. However, the average ability to dereplicate tapers off at ∼10 ppm, with modest improvement gained from better mass accuracy when querying focused databases of natural products. We also highlight some recent examples of how these platforms are applied to synthetic biology, and recent methods for dereplication and correlation of substructures using tandem MS data. We also offer this highlight to serve as a brief primer for those entering the field of mass spectrometry-based natural products discovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.