Evidence map›Paper›PMID 27376273›Full record

ReviewInternational journal of molecular sciences2016

Cell Models and Their Application for Studying Adipogenic Differentiation in Relation to Obesity: A Review.

Francisco Javier Ruiz-Ojeda, Azahara Iris Rupérez, Carolina Gomez-Llorente, Angel Gil, Concepción María Aguilera

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 369 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. iScience · 2026
    Article
  9. Article
  10. Anti-Adipogenic Effect of Secondary Metabolites Isolated fromInternational journal of molecular sciences · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Mixtures ofToxics · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Francisco Javier Ruiz-OjedaDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, Campus de Cartuja s/n, 18071, Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, Avenida del Conocimiento s/n, 18016, University of Granada, Granada 18071, Spain. fruizojeda@ugr.es.
Azahara Iris RupérezDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, Campus de Cartuja s/n, 18071, Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, Avenida del Conocimiento s/n, 18016, University of Granada, Granada 18071, Spain. azahararuperez@ugr.es.
Carolina Gomez-LlorenteDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, Campus de Cartuja s/n, 18071, Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, Avenida del Conocimiento s/n, 18016, University of Granada, Granada 18071, Spain. gomezll@ugr.es.
Angel GilDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, Campus de Cartuja s/n, 18071, Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, Avenida del Conocimiento s/n, 18016, University of Granada, Granada 18071, Spain. agil@ugr.es.
Concepción María AguileraDepartment of Biochemistry and Molecular Biology II, School of Pharmacy, Campus de Cartuja s/n, 18071, Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, Avenida del Conocimiento s/n, 18016, University of Granada, Granada 18071, Spain. caguiler@ugr.es.
Universidad de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last several years, the increasing prevalence of obesity has favored an intense study of adipose tissue biology and the precise mechanisms involved in adipocyte differentiation and adipogenesis. Adipocyte commitment and differentiation are complex processes, which can be investigated thanks to the development of diverse in vitro cell models and molecular biology techniques that allow for a better understanding of adipogenesis and adipocyte dysfunction associated with obesity. The aim of the present work was to update the different animal and human cell culture models available for studying the in vitro adipogenic differentiation process related to obesity and its co-morbidities. The main characteristics, new protocols, and applications of the cell models used to study the adipogenesis in the last five years have been extensively revised. Moreover, we depict co-cultures and three-dimensional cultures, given their utility to understand the connections between adipocytes and their surrounding cells in adipose tissue.

Indexed as

Models, BiologicalAdipogenesisAdipose TissueAnimalsCell Culture TechniquesCell DifferentiationCoculture TechniquesHumansObesityadipocytesbeige cellsbrown adipose tissuecell culture techniquescell differentiationin vitro techniquesobesitywhite adipose tissue

Identifiers

PMID27376273
PMCPMC4964416
OpenAlexW2473078753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.