Evidence map›Paper›PMID 27376129›Full record

ArticleBladder cancer (Amsterdam, Netherlands)2016

Independent Replication of Published Germline Polymorphisms Associated with Urinary Bladder Cancer Prognosis and Treatment Response.

Anne J Grotenhuis, Aleksandra M Dudek, Gerald W Verhaegh, Katja K Aben, J Alfred Witjes, Lambertus A Kiemeney, Sita H Vermeulen

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Article in Bladder cancer (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anne J GrotenhuisRadboud University Medical Center, Radboud Institute for Health Sciences , Nijmegen, The Netherlands.
Aleksandra M DudekRadboud University Medical Center, Radboud Institute for Molecular Life Sciences , Nijmegen, The Netherlands.
Gerald W VerhaeghRadboud University Medical Center, Radboud Institute for Molecular Life Sciences , Nijmegen, The Netherlands.
Katja K AbenRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands; Netherlands Comprehensive Cancer Organization, Utrecht, The Netherlands.
J Alfred WitjesRadboud University Medical Center, Radboud Institute for Molecular Life Sciences , Nijmegen, The Netherlands.
Lambertus A KiemeneyRadboud University Medical Center, Radboud Institute for Health Sciences , Nijmegen, The Netherlands.
Sita H VermeulenRadboud University Medical Center, Radboud Institute for Health Sciences , Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany studies investigated the prognostic or predictive relevance of single nucleotide polymorphisms (SNPs) in biologically plausible genes in urinary bladder cancer (UBC) patients. Most published SNP associations have never been replicated in independent patient series.

objectiveTo independently replicate all previously reported associations between germline SNPs and disease prognosis or treatment response in UBC.

methodsA Pubmed search was performed to identify studies published by July 1, 2014 reporting on germline SNP associations with UBC prognosis or treatment response. For the replication series, consisting of 1,284 non-muscle-invasive bladder cancer (NMIBC) and 275 muscle-invasive or metastatic bladder cancer (MIBC) patients recruited through the Netherlands Cancer Registry, detailed clinical data were retrieved from medical charts. Patients were genotyped using a genome-wide SNP array. SNP association with recurrence-free, progression-free, and overall survival (OS) within specific patient and treatment strata was tested using Cox regression analyses.

resultsFor only six of the 114 evaluated SNPs, the association with either UBC prognosis or treatment response was replicated at the

conclusionsNon-replicated genetic associations in the literature require cautious interpretation. This single replication does not provide definitive proof of association for the six SNPs, and non-replication of other SNPs may result from population-specific effects or the retrospective patient enrollment.

Indexed as

genetic association studiesprognosisreproducibility of resultssingle nucleotide polymorphismsTreatment outcomeurinary bladder neoplasms

Identifiers

PMID27376129
PMCPMC4927992

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