Evidence map›Paper›PMID 27375980›Full record

ArticleSpringerPlus2016

SNP haplotyping technique for evaluation of MGP 5' UTR power in osteoblast cells.

Abazar Roustazadeh, Seyed Hamidreza Monavari, Seyed Reza Hosseini Fard, Parisa Hassanpour, Amaneh Yarnazari, Mohammad Najafi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Abazar RoustazadehResearch Center for Non-Communicable Diseases and Biochemistry Department, Jahrom University of Medical Sciences, Jahrom, Iran.
Seyed Hamidreza MonavariVirology Department, Iran University of Medical Sciences, Tehran, Iran.
Seyed Reza Hosseini FardBiochemistry Department, Iran University of Medical Sciences, Tehran, Iran.
Parisa HassanpourBiochemistry Department, Iran University of Medical Sciences, Tehran, Iran.
Amaneh YarnazariBiochemistry Department, Iran University of Medical Sciences, Tehran, Iran.
Mohammad NajafiCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran ; Biochemistry Department, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IRJahrom University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix Gla protein (MGP) is involved in calcium trafficking and arterial calcification. The aim of study was to investigate the role of three polymorphisms within the MGP gene promoter region on reporter gene (luciferase) expression level. The fragments containing rs1800799 (C/T), rs1800802 (T/C), and rs1800801 (G/A) sites were constructed and transferred into human G292 osteoblast cells using pGL3-Basic plasmid. The reporter gene expression was calculated for the high and low frequency polymorphic haplotypes (CTG and TCA, respectively). Results showed that the reporter gene expression levels are not statistically different (p > 0.3). We concluded that the investigated polymorphic sites are not able to change the gene expression pattern in human G292 osteoblast cells.

Indexed as

HaplotypeMatrix Gla protein (MGP)OsteoblastPromoterSingle nucleotide polymorphism (SNP)

Identifiers

PMID27375980
PMCPMC4906098
OpenAlexW2431671116

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.