Evidence map›Paper›PMID 27375958›Full record

ArticleJournal of vaccines & vaccination

Pilin Vaccination Stimulates Weak Antibody Responses and Provides No Protection in a C57Bl/6 Murine Model of Acute

Grace A Maldarelli, Hanover Matz, Si Gao, Kevin Chen, Therwa Hamza, Harris G Yfantis, Hanping Feng, Michael S Donnenberg

Abstract read
In one paragraph

Article in Journal of vaccines & vaccination. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Recurrent Clostridioides difficile Infection: Current Clinical Management and Microbiome-Based Therapies.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. TargetingFrontiers in microbiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Grace A MaldarelliDepartment of Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Hanover MatzDepartment of Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Si GaoDepartment of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland, USA.
Kevin ChenDepartment of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland, USA.
Therwa HamzaDepartment of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland, USA.
Harris G YfantisDepartment of Pathology and Laboratory Medicine, VAMHCS, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Hanping FengDepartment of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland, USA.
Michael S DonnenbergDepartment of Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Funding

Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
Development of Vaccines against Clostridium difficile InfectionR01AI088748 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING, TZIPORI, SAUL R · 2010 to 2014
$3.1M
Epithelium, dendritic cells, and Clostridium difficile associated colitisR01DK084509 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING · 2010 to 2014
$1.7M
Vaccine Potential of Type IV Pilin from Clostridium difficleR03AI097953 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DONNENBERG, MICHAEL S · 2012 to 2013
$154k
Function and Vaccine Potential of a Clostridium difficile Type IV Pilus SubunitF30DK105539 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MALDARELLI, GRACE ANNE · 2014 to 2016
$125k
NIAID NIH HHS R01 AI088748NIAID NIH HHS R03 AI097953NIAID NIH HHS U19 AI109776NIDDK NIH HHS F30 DK105539NIDDK NIH HHS R01 DK084509
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibody generationClostridium difficileMouse modelPassive immunizationType IV pilins

Identifiers

PMID27375958
PMCPMC4927082

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.