ArticleBiomedical optics express2016
Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Multimodal optical coherence tomography and two-photon light sheet fluorescence microscopy for embryo imaging.Journal of biomedical optics · 2025Article
- Clipping spline: interactive, dynamic 4D volume clipping and analysis based on thin plate spline.Biomedical optics express · 2025Article
- Full-field optical coherence microscopy enables high-resolution label-free imaging of the dynamics of live mouse oocytes and early embryos.Communications biology · 2024Article
- Label-free biomedical optical imaging.Nature photonics · 2023Article
- Assessing the effects of prenatal poly-drug exposure on fetal brain vasculature using optical coherence angiography.Journal of biomedical optics · 2023Article
- Mouse embryo phenotyping with optical coherence tomography.Frontiers in cell and developmental biology · 2022Review
- Neural network-based image reconstruction in swept-source optical coherence tomography using undersampled spectral data.Light, science & applications · 2021Article
- Systematic imaging in medicine: a comprehensive review.European journal of nuclear medicine and molecular imaging · 2021Review
- Luminescence lifetime imaging of three-dimensional biological objects.Journal of cell science · 2021Article
- Acoustofluidic rotational tweezing enables high-speed contactless morphological phenotyping of zebrafish larvae.Nature communications · 2021Article
- Optical coherence tomography angiography to evaluate murine fetal brain vasculature changes caused by prenatal exposure to nicotine.Biomedical optics express · 2020Article
- Label-free optical imaging in developmental biology [Invited].Biomedical optics express · 2020Review
- OptiJ: Open-source optical projection tomography of large organ samples.Scientific reports · 2019Article
- Assessing the acute effects of prenatal synthetic cannabinoid exposure on murine fetal brain vasculature using optical coherence tomography.Journal of biophotonics · 2019Article
- Optical coherence elastography of cold cataract in porcine lens.Journal of biomedical optics · 2019Article
- Visualising the Cardiovascular System of Embryos of Biomedical Model Organisms with High Resolution Episcopic Microscopy (HREM).Journal of cardiovascular development and disease · 2018Review
- High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Evaluating the effects of maternal alcohol consumption on murine fetal brain vasculature using optical coherence tomography.Journal of biophotonics · 2018Article
- Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study.Biomedical optics express · 2017Article
- High-resolution Episcopic Microscopy (HREM) - Simple and Robust Protocols for Processing and Visualizing Organic Materials.Journal of visualized experiments : JoVE · 2017Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
We present an analysis of imaging murine embryos at various embryonic developmental stages (embryonic day 9.5, 11.5, and 13.5) by optical coherence tomography (OCT) and optical projection tomography (OPT). We demonstrate that while OCT was capable of rapid high-resolution live 3D imaging, its limited penetration depth prevented visualization of deeper structures, particularly in later stage embryos. In contrast, OPT was able to image the whole embryos, but could not be used in vivo because the embryos must be fixed and cleared. Moreover, the fixation process significantly altered the embryo morphology, which was quantified by the volume of the eye-globes before and after fixation. All of these factors should be weighed when determining which imaging modality one should use to achieve particular goals of a study.
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Registered trials
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