Evidence map›Paper›PMID 27375926›Full record

ArticleBiomedical optics express2016

Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows.

Kevin C Zhou, Brendan K Huang, Ute A Gamm, Vineet Bhandari, Mustafa K Khokha, Michael A Choma

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Article
  3. Optical Imaging of Cilia in the Head and Neck.Journal of clinical medicine · 2025
    Review
  4. Article
  5. Optica · 2023
    Article
  6. Article
  7. Article
  8. Development (Cambridge, England) · 2018
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kevin C ZhouDepartment of Biomedical Engineering, Yale University, 55 Prospect St., New Haven, Connecticut 06520, USA; Current affiliation: Department of Biomedical Engineering, Duke University, Fitzpatrick CIEMAS, 101 Science Dr., NC 27708, USA; kevin.zhou@duke.edu.
Brendan K HuangDepartment of Biomedical Engineering, Yale University, 55 Prospect St., New Haven, Connecticut 06520, USA.
Ute A GammDepartment of Radiology & Biomedical Imaging, Yale University, 333 Cedar St., New Haven, Connecticut 06510, USA.
Vineet BhandariDepartment of Pediatrics, Yale University, 333 Cedar St., New Haven, Connecticut 06510, USA.
Mustafa K KhokhaDepartment of Pediatrics, Yale University, 333 Cedar St., New Haven, Connecticut 06510, USA; Department of Genetics, Yale University, 333 Cedar St., New Haven, Connecticut 06510, USA.
Michael A ChomaDepartment of Biomedical Engineering, Yale University, 55 Prospect St., New Haven, Connecticut 06520, USA; Department of Radiology & Biomedical Imaging, Yale University, 333 Cedar St., New Haven, Connecticut 06510, USA; Department of Pediatrics, Yale University, 333 Cedar St., New Haven, Connecticut 06510, USA; Department of Applied Physics, Yale University, P.O. Box 208267, New Haven, Connecticut 06520, USA; michael.choma@yale.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
A system approach to the analysis of Heterotaxy Candiate GenesR01HD081379 · NICHD · YALE UNIVERSITY · PI KHOKHA, MUSTAFA K · 2014 to 2018
$2.7M
Quantitative optical imaging of cilia-driven fluid flowR01HL118419 · NHLBI · YALE UNIVERSITY · PI KHOKHA, MUSTAFA K · 2013 to 2017
$2.0M
Role of Angiogenic Agents in Alveolar Maturation and InjuryR01HL085103 · NHLBI · YALE UNIVERSITY · PI BHANDARI, VINEET · 2009 to 2013
$2.0M
NHLBI NIH HHS R01 HL085103NHLBI NIH HHS R01 HL118419NICHD NIH HHS R01 HD081379NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

We present a new OCT method for flow speed quantification and directional velocimetry: particle streak velocimetry-OCT (PSV-OCT). PSV-OCT generates two-dimensional, 2.5-vector component (vx ,|vy |,vz ) maps of microscale flow velocity fields. Knowledge of 2.5-vector components also enables the estimation of total flow speed. The enabling insight behind PSV-OCT is that tracer particles in sparsely-seeded fluid flow trace out streaks in (x,z,t)-space. The streak orientations in x-t and z-t yield vx and vz , respectively. The in-plane (x-z plane) residence time yields the out-of-plane speed |vy |. Vector component values are generated by fitting streaks to a model of image formation that incorporates equations of motion in 3D space. We demonstrate cross-sectional estimation of (vx ,|vy |,vz ) in two important animal models in ciliary biology: Xenopus embryos (tadpoles) and mouse trachea.

Indexed as

(110.4153) Motion estimation and optical flow(110.4500) Optical coherence tomography(120.7250) Velocimetry(170.3880) Medical and biological imaging(280.2490) Flow diagnostics

Identifiers

PMID27375926
PMCPMC4929663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.