ArticlePakistan journal of medical sciences
Olfactory neuroblastoma: A clinicopathological experience of a rare entity from Pakistan.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 8 citations in OpenAlex.
- The 100 most-cited papers on esthesioneuroblastoma: a bibliometric analysis.Annals of medicine and surgery (2012) · 2025Review
- A Review on Esthesioneuroblastoma.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Esthesioneuroblastoma Presenting with Bilateral Proptosis and Blindness in a Child: A Case Report.Journal of clinical and diagnostic research : JCDR · 2017Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
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Abstract
objectivesTo present the clinicopathological experience of Olfactory Neuroblastoma (ONB) with emphasis on histopathological and immunohistochemical features.
methodsA descriptive cross-sectional study was done on 36 cases of ONB, selected by non-probability purposive sampling. Theses cases of ONB were retrieved and reviewed from surgical pathology database of Aga Khan University Hospital reported between January 1993 and March 2015.
resultsTumor size and age of presentation was wide in range without any distinct bimodal distribution. Nasal cavity was most common site along with involvement of paranasal sinuses. More than 50% cases had Kadish stage A. Microscopically, most cases were Grade-1 and majority showed partial or complete lobular architecture. Neurofibrillary matrix was observed in 2/3(rd) of cases. Among immunohistochemical markers, Neuron Specific Enolase was most frequently expressed. Unusual positive expression of Cytokeratin AE1/AE3 and Cytokeratin CAM5.2 was also seen focally in few cases.
conclusionThe ONB has great variability of histological and clinical presentation, and immunohistochemical markers are useful to differentiate from more common small round blue cell tumours of nasal cavity.
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