ArticlePakistan journal of medical sciences
Importance of immature platelet fraction as predictor of immune thrombocytopenic purpura.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Immature Platelet Fraction and Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisTrial
- Reticulated Platelets and an Optimal Model for Differentiating Thrombocytopenia Etiologies.EJHaem · 2026Article
- Article
- The association between immature platelet count and clinical characteristics in pediatric immune thrombocytopenia.Research and practice in thrombosis and haemostasis · 2026Observational
- Molecular diagnosis of inherited platelet disorders: a tale of two realities - advanced vs. resource-limited setting.Thrombosis journal · 2025Review
- Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition.International journal of hematology · 2024Article
- Article
- CLINICAL RELEVANCE OF EXTENDED PLATELET INDICES IN THE DIAGNOSIS OF IMMUNE THROMBOCYTOPENIA.Acta clinica Croatica · 2021Article
- Immature Platelet Fraction: Its Clinical Utility in Thrombocytopenia Patients.Journal of laboratory physicians · 2021Article
- Evaluation of Immature Platelet Fraction in Lower Respiratory Tract Infections: A Retrospective Study.Cureus · 2020Article
- Immature platelet fraction based diagnostic predictive scoring model for immune thrombocytopenia.The Korean journal of internal medicine · 2020Article
- Mean Platelet Volume and Immature Platelet Fraction in Autoimmune Disorders.Frontiers in medicine · 2017Review
- Clinical features and outcome in paediatric newly diagnosed immune thrombocytopenic purpura in a tertiary care centre.Pakistan journal of medical sciencesArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveImmune thrombocytopenic purpura (ITP) is a clinical syndrome in which a decreased number of circulating platelets (thrombocytopenia) manifests as a bleeding tendency, easy bruising (purpura) or extravasation of blood from capillaries into skin and mucous membranes (petechiae). The diagnosis of ITP can be made clinically on the basis of symptoms, we need to see if ITP can be confirmed in patients by quantification of residual RNA containing immature platelets (megakaryocytic mass) or immature platelets fraction (IPF) using automated hematology analyzers (Sysmex XE-2100).
methodsIn order to check the efficacy of IPF% parameter of Sysmex XE-2100 a total of 231 patients of thrombocytopenia were included in this study. Complete blood count (CBC) was estimated. The data was statistically analyzed by SPSS version 17.
resultsAbout 62 patients were diagnosed as ITP and 169 patients were diagnosed as non ITP on the basis of clinical history. The mean IPF % value of ITP patients was 16.39% and the IPF % value of Non ITP patients was ~7.69% respectively. There was no significant difference in IPF% values with respect to time between sampling and acquisition of complete blood count. The diagnostic sensitivity of IPF% as biomarker for ITP and non-ITP was 85.71% (95%CI: 84.04% to 85.96%) and 41.76% (95% CI: 39.87% to 43.65%).
conclusionThe mean IPF % value by Sysmex XE-2100 can be used to predict ITP.
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