ReviewFrontiers in genetics2016
Reviving the RNA World: An Insight into the Appearance of RNA Methyltransferases.
Review in Frontiers in genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Neural stem cell heterogeneity in adult hippocampus.Cell regeneration (London, England) · 2025Review
- Methylation in cornea and corneal diseases: a systematic review.Cell death discovery · 2024Review
- DNA Methyltransferases: From Evolution to Clinical Applications.International journal of molecular sciences · 2022Review
- mInternational journal of molecular sciences · 2022Article
- Making Sense of "Nonsense" and More: Challenges and Opportunities in the Genetic Code Expansion, in the World of tRNA Modifications.International journal of molecular sciences · 2022Review
- More than a duologue: In-depth insights into epitranscriptomics and ferroptosis.Frontiers in cell and developmental biology · 2022Review
- Hypermodified DNA in Viruses of E. coli and Salmonella.EcoSal Plus · 2021Review
- Identification of a DNA Methylation-Based Prognostic Signature for Patients with Triple-Negative Breast Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Development and validation of a novel 15-CpG-based signature for predicting prognosis in triple-negative breast cancer.Journal of cellular and molecular medicine · 2020Article
- Hypermethylation of tumor necrosis factor decoy receptor gene in non-small cell lung cancer.Oncology letters · 2020Article
- Methylation deficiency disrupts biological rhythms from bacteria to humans.Communications biology · 2020Article
- A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalianNAR genomics and bioinformatics · 2020Article
- Reassessment of Viroid RNA Cytosine Methylation Status at the Single Nucleotide Level.Viruses · 2019Article
- The role of mRNA mCell & bioscience · 2019Review
- Folate promotes S-adenosyl methionine reactions and the microbial methylation cycle and boosts ruminants production and reproduction.AMB Express · 2018Review
- Next-Generation Sequencing-Based RiboMethSeq Protocol for Analysis of tRNA 2'-O-Methylation.Biomolecules · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA, the earliest genetic and catalytic molecule, has a relatively delicate and labile chemical structure, when compared to DNA. It is prone to be damaged by alkali, heat, nucleases, or stress conditions. One mechanism to protect RNA or DNA from damage is through site-specific methylation. Here, we propose that RNA methylation began prior to DNA methylation in the early forms of life evolving on Earth. In this article, the biochemical properties of some RNA methyltransferases (MTases), such as 2'-O-MTases (Rlml/RlmN), spOUT MTases and the NSun2 MTases are dissected for the insight they provide on the transition from an RNA world to our present RNA/DNA/protein world.
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