Evidence map›Paper›PMID 27375624›Full record

ReviewFrontiers in immunology2016

Unique Transcompartmental Bridge: Antigen-Presenting Cells Sampling across Endothelial and Mucosal Barriers.

Frederick Allen, Alexander A Tong, Alex Y Huang

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Poultry gut health and beyond.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Inactivated probioticJournal of inflammation research · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Frederick AllenDepartment of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH , USA.
Alexander A TongDepartment of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH , USA.
Alex Y HuangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Angie Fowler AYA Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.
University School · USRainbow Babies & Children's Hospital · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARK R CHANCE · 1987 to 2026
$142.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Mechanistic Dynamic Study of Intranodal Chemokine-aided Antitumor Immune PrimingR01CA154656 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 2011 to 2015
$1.7M
Novel mechanisms of immune activation following allogeneic, hematopoietic stem cell transplantationR01HL111682 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI COOKE, KENNETH R, LETTERIO, JOHN JAMES · 2013 to 2016
$1.6M
Cdk5 signaling in ICN1-induced T Cell LeukemogenesisR21CA181875 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN, LETTERIO, JOHN JAMES · 2015 to 2016
$379k
INFLAMMATORY CHEMOKINE CCL3 IN THE TUMOR MICROENVIRONMENT LEADS TO ENHANCED ANTITUMOR IMMUNE DEVELOPMENT IN THE DRAINING LYMPH NODEF31CA192874 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI ALLEN, FREDERICK · 2014 to 2016
$96k
NCI NIH HHS F31 CA192874NCI NIH HHS P30 CA043703NCI NIH HHS R01 CA154656NCI NIH HHS R21 CA181875NHLBI NIH HHS R01 HL111682NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Potentially harmful pathogens can gain access to tissues and organ systems through body sites that are in direct contact with the outside environment, such as the skin, the gut, and the airway mucosa. Antigen-presenting cells (APCs) represent a bridge between the innate and adaptive immunity, and their capacity for constant immune surveillance and rapid sampling of incoming pathogens and other potentially harmful antigens is central for mounting an effective and robust protective host response. The classical view is that APCs perform this task efficiently within the tissue to sense invading agents intra-compartmentally. However, recent data based on high resolution imaging support an additional transcompartmental surveillance behavior by APC by reaching across intact physical barriers. In this review, we summarize intravital microscopic evidences of APC to sample antigens transcompartmentally at the gut mucosa and other body sites.

Indexed as

antigen captureantigen presentationantigen-presenting cellcell migrationdendritic cellmucosal immunityT cell activationtranscompartment

Identifiers

PMID27375624
PMCPMC4901051
OpenAlexW2411334560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.