ArticleFrontiers in microbiology2016
Enterocyte-Associated Microbiome of the Hadza Hunter-Gatherers.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Advances in integrative African genomics.Trends in genetics : TIG · 2022Review
- The Spatial and Temporal Characterization of Gut Microbiota in Broilers.Frontiers in veterinary science · 2021Article
- The microbiome of captive hamadryas baboons.Animal microbiome · 2020Article
- Probiotics: current landscape and future horizons.Future science OA · 2019Review
- Effects of the captive and wild environment on diversity of the gut microbiome of deer mice (Peromyscus maniculatus).The ISME journal · 2019Article
- The Enterococcus: a Model of Adaptability to Its Environment.Clinical microbiology reviews · 2019Review
- HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation.Current opinion in infectious diseases · 2017Review
- Oral health in transition: The Hadza foragers of Tanzania.PloS one · 2017Article
- Differential fecal microbiota are retained in broiler chicken lines divergently selected for fatness traits.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By means of a recently developed non-invasive ex vivo minimal model based on the interaction of the human enterocyte-like HT29 cell line and fecal slurries, we explored the enterocyte-associated microbiome of 21 Hadza hunter-gatherers and nine urban living Italians. Though reductionist, this model allows inferring the microbiota structural and functional arrangement as it interacts with enterocytes. Microbial suspensions obtained from Hadza or Italian stools were first evaluated for structural integrity by high resolution-scanning electron microscopy and co-incubated with HT29 cell monolayers. The enterocyte adherent microbiota fraction was then characterized by 16S rRNA gene sequencing and predictive functional profiling using PICRUSt. Compared to Italians, the Hadza enterocyte-associated microbiome was characterized by a greater amount of adhesive microorganisms with pathogenic potential, such as Proteobacteria, Erysipelotrichaceae, Enterococcus, Clostridium and Sarcina. These compositional characteristics were reflected in a functional enrichment in membrane transport, signal transduction, signaling molecules and interaction. Our results depict a new interesting mutualistic configuration of the enterocyte-associated microbiome in Hadza, stressing the importance of microbe-host interaction at the mucosal surface along the course of human evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.