Evidence map›Paper›PMID 27375462›Full record

ArticleFrontiers in human neuroscience2016

Change in Mean Frequency of Resting-State Electroencephalography after Transcranial Direct Current Stimulation.

Tjeerd W Boonstra, Stevan Nikolin, Ann-Christin Meisener, Donel M Martin, Colleen K Loo

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05623072 (The Effect of tDCS on Emotion Recognition and EEG Oscillations in Healthy Adults), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05623072 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of tDCS on Emotion Recognition and EEG Oscillations in Healthy Adults

TypeinterventionalSponsorIstanbul Medipol University HospitalRan2022 to 2023Enrolled56ConditionsEmotion RecognitionArmsActive tDCS, Sham tDCS
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  18. Hippocampal atrophy and quantitative EEG markers in mild cognitive impairment in temporal lobe epilepsy versus extra-temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tjeerd W BoonstraSchool of Psychiatry, University of New South WalesSydney, NSW, Australia; Black Dog Institute, University of New South WalesSydney, NSW, Australia.
Stevan NikolinSchool of Psychiatry, University of New South WalesSydney, NSW, Australia; Black Dog Institute, University of New South WalesSydney, NSW, Australia.
Ann-Christin MeisenerSchool of Psychiatry, University of New South WalesSydney, NSW, Australia; Institute of Cognitive Science, University of OsnabruckLower Saxony, Germany.
Donel M MartinSchool of Psychiatry, University of New South WalesSydney, NSW, Australia; Black Dog Institute, University of New South WalesSydney, NSW, Australia.
Colleen K LooSchool of Psychiatry, University of New South WalesSydney, NSW, Australia; Black Dog Institute, University of New South WalesSydney, NSW, Australia; Department of Psychiatry, St. George Hospital, South Eastern Sydney HealthSydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is proposed as a tool to investigate cognitive functioning in healthy people and as a treatment for various neuropathological disorders. However, the underlying cortical mechanisms remain poorly understood. We aim to investigate whether resting-state electroencephalography (EEG) can be used to monitor the effects of tDCS on cortical activity. To this end we tested whether the spectral content of ongoing EEG activity is significantly different after a single session of active tDCS compared to sham stimulation. Twenty participants were tested in a sham-controlled, randomized, crossover design. Resting-state EEG was acquired before, during and after active tDCS to the left dorsolateral prefrontal cortex (15 min of 2 mA tDCS) and sham stimulation. Electrodes with a diameter of 3.14 cm(2) were used for EEG and tDCS. Partial least squares (PLS) analysis was used to examine differences in power spectral density (PSD) and the EEG mean frequency to quantify the slowing of EEG activity after stimulation. PLS revealed a significant increase in spectral power at frequencies below 15 Hz and a decrease at frequencies above 15 Hz after active tDCS (P = 0.001). The EEG mean frequency was significantly reduced after both active tDCS (P < 0.0005) and sham tDCS (P = 0.001), though the decrease in mean frequency was smaller after sham tDCS than after active tDCS (P = 0.073). Anodal tDCS of the left DLPFC using a high current density bi-frontal electrode montage resulted in general slowing of resting-state EEG. The similar findings observed following sham stimulation question whether the standard sham protocol is an appropriate control condition for tDCS.

Indexed as

cortical oscillationsDLPFCEEG mean frequencyhealthy volunteertDCS

Identifiers

PMID27375462
PMCPMC4893480

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.