Evidence map›Paper›PMID 27375446›Full record

ArticleFrontiers in behavioral neuroscience2016

Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains using a Novel Automated Home Cage Analysis System.

Rasneer S Bains, Heather L Cater, Rowland R Sillito, Agisilaos Chartsias, Duncan Sneddon, Danilo Concas, Piia Keskivali-Bond, Timothy C Lukins, Sara Wells, Abraham Acevedo Arozena and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 113 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rasneer S BainsMary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK.
Heather L CaterMary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK.
Rowland R SillitoActual Analytics Ltd Edinburgh, UK.
Agisilaos ChartsiasActual Analytics Ltd Edinburgh, UK.
Duncan SneddonMammalian Genetics Unit, Medical Research Council Harwell Oxfordshire, UK.
Danilo ConcasMary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK.
Piia Keskivali-BondMary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK.
Timothy C LukinsActual Analytics Ltd Edinburgh, UK.
Sara WellsMary Lyon Centre, Medical Research Council Harwell Oxfordshire, UK.
Abraham Acevedo ArozenaMammalian Genetics Unit, Medical Research Council Harwell Oxfordshire, UK.
Patrick M NolanMammalian Genetics Unit, Medical Research Council Harwell Oxfordshire, UK.
J Douglas ArmstrongActual Analytics LtdEdinburgh, UK; School of Informatics, University of EdinburghEdinburgh, UK.
Medical Research Council · GBUniversity of Edinburgh · GB

Funding

Medical Research Council MC_U142684171Medical Research Council MC_U142684173Medical Research Council MC_UP_1502/1Medical Research Council MC_UP_A390_1106National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/C012201/1
6 · The paper itself

Abstract

Central nervous system disorders such as autism as well as the range of neurodegenerative diseases such as Huntington's disease are commonly investigated using genetically altered mouse models. The current system for characterizing these mice usually involves removing the animals from their home-cage environment and placing them into novel environments where they undergo a battery of tests measuring a range of behavioral and physical phenotypes. These tests are often only conducted for short periods of times in social isolation. However, human manifestations of such disorders are often characterized by multiple phenotypes, presented over long periods of time and leading to significant social impacts. Here, we have developed a system which will allow the automated monitoring of individual mice housed socially in the cage they are reared and housed in, within established social groups and over long periods of time. We demonstrate that the system accurately reports individual locomotor behavior within the group and that the measurements taken can provide unique insights into the effects of genetic background on individual and group behavior not previously recognized.

Indexed as

C57BL/6 micecircadian rhythminbred mouse strainsmouse behaviormouse modelsstrain differences

Identifiers

PMID27375446
PMCPMC4901040
OpenAlexW2410506857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.