ArticleFrontiers in neuroscience2016
The Fallacy of Univariate Solutions to Complex Systems Problems.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Using deep learning to identify brain networks mediating cognitive and motor impairments in alcohol use disorder.Translational psychiatry · 2026Article
- Machine learning algorithm reveals neurodevelopmental signatures of combined family income and neighborhood disadvantage in adolescents.Scientific reports · 2026Article
- Complexity and risk factor research in mental disorders: better think twice.Frontiers in psychiatry · 2026Article
- Review
- The sleep EEG envelope is a novel, neuronal firing-based human biomarker.Scientific reports · 2022Article
- Prediction of remission among patients with a major depressive disorder based on the resting-state functional connectivity of emotion regulation networks.Translational psychiatry · 2022Article
- Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration.Frontiers in psychiatry · 2022Article
- Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.Neuroscience and biobehavioral reviews · 2021Review
- Machine Learning With Neuroimaging: Evaluating Its Applications in Psychiatry.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Review
- The perils of premature phenotyping in COVID-19: a call for caution.The European respiratory journal · 2020Article
- Multivariate classification of schizophrenia and its familial risk based on load-dependent attentional control brain functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- New statistical method identifies cytokines that distinguish stool microbiomes.Scientific reports · 2019Article
- To each, his/her own.Neuro-oncology · 2019Article
- Tourette syndrome research highlights from 2016.F1000Research · 2017Review
- Functional connectome signature of general psychopathology in middle-aged and older adults: Evidence from multi-cohort, multi-ethnic analyses.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Complex biological systems, by definition, are composed of multiple components that interact non-linearly. The human brain constitutes, arguably, the most complex biological system known. Yet most investigation of the brain and its function is carried out using assumptions appropriate for simple systems-univariate design and linear statistical approaches. This heuristic must change before we can hope to discover and test interventions to improve the lives of individuals with complex disorders of brain development and function. Indeed, a movement away from simplistic models of biological systems will benefit essentially all domains of biology and medicine. The present brief essay lays the foundation for this argument.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.