ArticleFrontiers in neuroscience2016
Multimodal 7T Imaging of Thalamic Nuclei for Preclinical Deep Brain Stimulation Applications.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Enhancing 7T MRI for deep brain stimulation with deep-learning based image reconstruction and dynamic parallel transmission.NeuroImage. Clinical · 2026Article
- Predicting Post-Operative Side Effects in VIM MRgFUS Based on THalamus Optimized Multi Atlas Segmentation (THOMAS) on White-Matter-Nulled MRI: A Retrospective Study.AJNR. American journal of neuroradiology · 2025Article
- Active contact proximity to the cerebellothalamic tract predicts initial therapeutic current requirement with DBS for ET: an application of 7T MRI.Frontiers in neurology · 2023Article
- High resolution and contrast 7 tesla MR brain imaging of the neonate.Frontiers in radiology · 2023Article
- Article
- Neuroimaging at 7 Tesla: a pictorial narrative review.Quantitative imaging in medicine and surgery · 2022Review
- High-resolution mapping and digital atlas of subcortical regions in the macaque monkey based on matched MAP-MRI and histology.NeuroImage · 2021Article
- Thalamic volume and fear extinction interact to predict acute posttraumatic stress severity.Journal of psychiatric research · 2021Observational
- High-resolution Structural Magnetic Resonance Imaging and Quantitative Susceptibility Mapping.Magnetic resonance imaging clinics of North America · 2021Review
- Multiparametric MRI for Characterization of the Basal Ganglia and the Midbrain.Frontiers in neuroscience · 2021Article
- Automated thalamic nuclei segmentation using multi-planar cascaded convolutional neural networks.Magnetic resonance imaging · 2020Article
- Frequency-dependent spike-pattern changes in motor cortex during thalamic deep brain stimulation.Journal of neurophysiology · 2020Article
- MRI and tractography techniques to localize the ventral intermediate nucleus and dentatorubrothalamic tract for deep brain stimulation and MR-guided focused ultrasound: a narrative review and update.Neurosurgical focus · 2020Article
- Thalamus Optimized Multi Atlas Segmentation (THOMAS): fast, fully automated segmentation of thalamic nuclei from structural MRI.NeuroImage · 2019Article
- 3T MRI Whole-Brain Microscopy Discrimination of Subcortical Anatomy, Part 2: Basal Forebrain.AJNR. American journal of neuroradiology · 2019Article
- High-resolution local field potentials measured with deep brain stimulation arrays.Journal of neural engineering · 2018Article
- Future Brain and Spinal Cord Volumetric Imaging in the Clinic for Monitoring Treatment Response in MS.Current treatment options in neurology · 2018Review
- Deep brain stimulation induces sparse distributions of locally modulated neuronal activity.Scientific reports · 2018Article
- Particle swarm optimization for programming deep brain stimulation arrays.Journal of neural engineering · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Precise neurosurgical targeting of electrode arrays within the brain is essential to the successful treatment of a range of brain disorders with deep brain stimulation (DBS) therapy. Here, we describe a set of computational tools to generate in vivo, subject-specific atlases of individual thalamic nuclei thus improving the ability to visualize thalamic targets for preclinical DBS applications on a subject-specific basis. A sequential nonlinear atlas warping technique and a Bayesian estimation technique for probabilistic crossing fiber tractography were applied to high field (7T) susceptibility-weighted and diffusion-weighted imaging, respectively, in seven rhesus macaques. Image contrast, including contrast within thalamus from the susceptibility-weighted images, informed the atlas warping process and guided the seed point placement for fiber tractography. The susceptibility-weighted imaging resulted in relative hyperintensity of the intralaminar nuclei and relative hypointensity in the medial dorsal nucleus, pulvinar, and the medial/ventral border of the ventral posterior nuclei, providing context to demarcate borders of the ventral nuclei of thalamus, which are often targeted for DBS applications. Additionally, ascending fiber tractography of the medial lemniscus, superior cerebellar peduncle, and pallidofugal pathways into thalamus provided structural demarcation of the ventral nuclei of thalamus. The thalamic substructure boundaries were validated through in vivo electrophysiological recordings and post-mortem blockface tissue sectioning. Together, these imaging tools for visualizing and segmenting thalamus have the potential to improve the neurosurgical targeting of DBS implants and enhance the selection of stimulation settings through more accurate computational models of DBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.